Results 81 to 90 of about 1,751,019 (301)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Juan Bautista Juanini (1636-1691) i Joan d'Alòs i Serradora (1617-1695) [PDF]

open access: yes, 2009
Our work show a typical scientific relatioship in the last years of the XVIIthn century, inside the renovation movement in the science and medicine of these years.
Cobo Gómez, Jesús V.
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Time-domain synthesis by means of trigonometric polynomial approximations [PDF]

open access: yes, 1956
"January 5, 1956." "This report is based on a thesis submitted to the Department of Electrical Engineering, M.I.T., July 1955, in partial fulfillment of the requirements for the degree of Doctor of Science."Bibliography: p.

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Sponsored Programs Annual Report / Graduate School of Engineering and Applied Sciences, Fiscal Year 2006 [PDF]

open access: yes, 2006
The Graduate School of Engineering and Applied Sciences (GSEAS) at the Naval Postgraduate School in Monterey, California provides graduate education leading to the master of science, engineer, doctor of philosophy, and doctor of engineering degrees ...

core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Go Call the Doctor & Be Quick or Anti Calomel [PDF]

open access: yes
Physicians of the highest rankTo pay their fees would need a bankCombine all wisdom art and skillScience and sense in, science and sense in, science and sense inCalomel, Calomel, Calomel, Calomel When Mr.
Hutchinson, Judson Joseph
core   +1 more source

Applications in Clinical Administration Medical Record Service Health GPIB PAULUS MENTENG Using Visual Basic 6.0 [PDF]

open access: yes, 2009
Currently a very rapid development of computer science, the application is already widespread across the homeland Indonesia.Hal due speed and completeness in data processing, accuracy and data processing plays a very important.
DAMAILAWASTU, K. J. (KLAUDA)
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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