Results 61 to 70 of about 1,751,019 (301)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Programa de Pós-Graduação em Geologia - Teses Defendidas 2000 - Doutorado - Instituto de Geociências - UFRJ [PDF]

open access: yesAnuário do Instituto de Geociências, 2000
33 Anuário do Instituto de Geociências - UFRJ Volume 23 / 2000 Programa de Pós-Graduação em Geologia Teses Defendidas - Doutorado Nome: Renato Fontes Guimarães Orientador: Nelson Ferreira Fernandes Título: Utilização de um modelo de previsão de ...
doaj  

The effect of firm-specific advantages and entry strategy on performance in Japanese foreign investments : evidences from four ASEAN countries [PDF]

open access: yes, 2001
筑波大学University of Tsukuba博士(経営工学)Doctor of Management Science and Engineering2000【要旨 ...
44990, Siripaisalpipat, Pimonwan
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Landscape compositions of stone and plants in the heritage of professor L.I. Rubtsov

open access: yesІнтродукція Рослин, 2012
Doctor of science (biology) L.I. Rubtsov`s theoretical developments and results of activity in creating compositions of stone and plants are represented.
E.L. Rubtsova
doaj   +1 more source

The Gendered Culture of Scientific Competence: A Study of Scientist Characters in Doctor Who 1963-2013

open access: yes, 2016
The present study examines the relationship between gender and scientific competence in fictional representations of scientists in the British science fiction television program Doctor Who.
Morgain, Rachel, Orthia, Lindy
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Lives of Elderly Residents in Nursing Homes (Panti Jompo): Social Dynamics, Well-Being, and Challenges in Later Life [PDF]

open access: yesBIO Web of Conferences
This study aims to examine the social dynamics, well-being, and challenges faced by elderly residents living in nursing homes. Using a qualitative approach, it explores the daily experiences of the elderly within the nursing home environment, including ...
Solina Emmy   +6 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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