Results 71 to 80 of about 273,044 (344)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2021 Un ensemble $S \subset \mathbb{Z}^d$ est \emph{convexe discret} si $\conv(S) \cap \mathbb{Z}^d = S$, où $\conv(S)$ est l'enveloppe convexe de $S$.Ici, nous considérons plusieurs problèmes algorithmiques traitant de la reconnaissance d'ensembles convexes discrets ainsi que de la détection de sous ensembles convexes discrets.Nous montrons que l ...
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Lives of Elderly Residents in Nursing Homes (Panti Jompo): Social Dynamics, Well-Being, and Challenges in Later Life [PDF]
BIO Web of ConferencesThis study aims to examine the social dynamics, well-being, and challenges faced by elderly residents living in nursing homes. Using a qualitative approach, it explores the daily experiences of the elderly within the nursing home environment, including ...
Solina Emmy +6 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Honorary Doctor of Science presented to Neil Armstrong from University of Cincinnati, June 13, 1982
, 2013 Honorary Doctor of Science from University of Cincinnati, June 13 ...
University of Cincinnati +1 more
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Person-centered pain management - science and art
, 2013 We are witnessing an unprecedented development of the medical science, which promises to revolutionize health care and improve patients' health outcomes. However, the core of the medical profession has always been and will be the relationship between the
Janjanin, Mladen +2 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Landscape compositions of stone and plants in the heritage of professor L.I. Rubtsov
Інтродукція Рослин, 2012 Doctor of science (biology) L.I. Rubtsov`s theoretical developments and results of activity in creating compositions of stone and plants are represented.
E.L. Rubtsova
doaj +1 more source
Canon, myth, and memory in Doctor Who
, 2010 For Doctor Who, issues of canonicity are more ambiguous than for other long-running science fiction series such as Star Trek and Star Wars: unlike the producers of the two American franchises, the BBC has never offered an official edict as to what ...
Harvey, Colin B. (R17686)
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