Results 91 to 100 of about 273,044 (344)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Julius Bernhard Haffner receives an honorary Doctor of Science degree
, 1956 Julius Bernhard Haffner receives an honorary Doctor of Science degree during the 1956 Commencement ceremony. Also on stage are College of Mines Dean J.D. Forrester (left), Registrar Donald Dudley DuSault (behind), and University of Idaho President Donald
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Certificate, Honorary Degree of Doctor of Science, Thiel College, 1932
, 2008 Certificate of Honorary Degree of Doctor of Science from Thiel College in Greenville, PA, December ...
Thiel College
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The church militant? The Church of England, humanity and the future in Doctor Who [PDF]
, 2013 Marcus Harmes, meanwhile, considers different portrayals of the Church of England in the Russell T. Davies and Stephen Moffat eras. Whereas Davies's episodes featured the Church both literally and metaphorically under attack, Moffat portrays a ...
Harmes, Marcus
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The Doctor and the Professor [Blog post]
, 2015 ‘Remember the Red Indian. When he saw the first steam train, his savage mind thought it an illusion, too.’ Thus begins Doctor Who in 1963 when two teachers Ian and Barbara enter a police box and swiftly find themselves patronised by an alien time ...
Harmes, Marcus
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