Results 81 to 90 of about 4,453,304 (252)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Exeter at CLEF 2003: Cross-language spoken document retrieval experiments [PDF]

open access: yes, 2004
Cross-Language Spoken Document Retrieval (CLSDR) combines both the complexities of retrieval from collections characterized by speech transcription errors and language translation issues between search requests and documents.
Lam-Adesina, Adenike M.   +3 more
core   +3 more sources

THE INFORMATION SYSTEM AS A TOOL TO MANAGE R&D AT THE NATIONAL ACADEMY OF PEDAGOGICAL SCIENCES OF UKRAINE

open access: yesÌнформаційні технології в освіті, 2013
The objectives of R&D management in NAPS of Ukraine are considered scientific activity as well as connected document types. There is the analysis of requirements for information systems to manage R&D, named “R&D”.
N. Zadorozhna, S. Tukalo, B. Petrushko
doaj  

Using Heider’s Epistemology of Thing and Medium for Unpacking the Conception of Documents: Gantt Charts and Boundary Objects

open access: yesProceedings from the Document Academy, 2015
Documents play a central role for many organizational processes. Current conceptualizations of documents predominantly engage with documents in two different ways.
Sebastian Boell, Florian Hoof
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Enfatizando o processo

open access: yesSignificação: Revista de Cultura Audiovisual, 2019
In response to the concept of an artistic project, technology has a double role: it hides the performer behind the computer and extends the possibilities by representing him/her.
Ana Carvalho
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Laws of External and Internal Design of Business Letter (on the French Materials)

open access: yesВестник Волгоградского государственного университета: Серия 2. Языкознание, 2016
This paper discusses the basic rules of the external and internal design of the business letter. It clarifies that a business letter is a special type of document that has legal effect, so special attention here is given to its design.
Jerome Baghana, Elena Leonidovna Kuksova
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Interlending and document supply

open access: yes, 1994
SIGLEAvailable from British Library Document Supply Centre- DSC:4534.4631(3) / BLDSC - British Library Document Supply CentreGBUnited ...
Swires, A.J   +1 more
core  

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