Results 71 to 80 of about 122,251 (308)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The legal protection of databases from copyright to dataright.

, 1989
PhDThe vast and sweeping developments, which have occurred recently in the fields of computers, telecommunications and information technologies have stimulated the formation of a new global market of electronic information services and products, in ...
Bouganim, Victor H.
core  

GenIsisWeb : la herramienta para publicar en Internet las bases de datos CDS/ISIS

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2003
El objetivo de la reseña es presentar GenIsisWeb, un programa que asiste en la publicación de bases de datos en Internet. Tras una breve descripción técnica y partiendo de una base de datos previamente creada con CDS/ISIS, se muestra el proceso completo ...
Alcàzar, Noemi, Chávez, Sergi
doaj  

GenAI-Assisted Database Deployment for Heterogeneous Indigenous–Native Ethnographic Research Data

Applied Sciences
In ethnographic research, data collected through surveys, interviews, or questionnaires in the fields of sociology and anthropology often appear in diverse forms and languages.
Reen-Cheng Wang, David Yang, Ming-Che Hsieh, Yi-Cheng Chen, Weihsuan Lin   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

TIJAH: embracing IR methods in XML databases [PDF]

, 2005
This paper discusses our participation in INEX (the Initiative for the Evaluation of XML Retrieval) using the TIJAH XML-IR system. TIJAH's system design follows a `standard' layered database architecture, carefully separating the conceptual, logical and ...
Mihajlovic, V., List, Johan, Mihajlović, Vojkan, Ramirez Camps, Georgina, Blok, H.E. (Henk Ernst), de Vries, Arjen P., de Vries, A.P., List, J.A. (Johan), Ramírez, G., List, J., Blok, H.E., Ramirez Camps, G. (Georgina), Vries, A.P. de, Blok, Henk Ernst, List, J.A., Vries, Arjen, Ramirez, Georgina, Hiemstra, Djoerd, Vries, A.P. (Arjen) de, Hiemstra, D.   +19 more
core   +1 more source

The ARQUIBANC Project: Location, Recovery, Arrangement, and Dissemination of Catalan Private Archives and Documents

Digital Medievalist, 2012
The aim of this paper is to present the first steps of the Arquibanc Project that has as a main objective to recover archives that are in private hands to make them available to the scientific community.
Elena Cantarell, Mireia Comas
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluation of a Prototype Interface for Structured Document Retrieval

, 2003
Document collections often display either internal structure, in the form of the logical arrangement of document components, or external structure, in the form of links between documents.
Dunlop, M.D., Reid, J.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source