Results 51 to 60 of about 4,367,374 (298)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
GSYAtools/NoSQL-document-databases: Security design for NoSQL document databases
<p>Research papers related to the design of documentary databases including security aspects.</p ...
Carlos
core +1 more source
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2003 El objetivo del texto es determinar si las revistas incluidas en la base de datos Science citation index.Expanded (SCI-E) son revistas fuente como lo son las que se incluyen en Science citation index (SCI) para la posterior publicación de los indicadores
Badia Segura, Maria +2 more
doaj
Blind Queries Applied to JSON Document Stores
Information, 2019 Social Media, Web Portals and, in general, information systems offer their own Application Programming Interfaces (APIs), used to provide large data sets concerning every aspect of day-by-day life.
Stefania Marrara +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Query Evaluation in Deductive Databases [PDF]
, 1990 It is desirable to answer queries posed to deductive databases by computing fixpoints because such computations are directly amenable to set-oriented fact processing.
Bry, François
core +1 more source
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2000 Es descriuen els passos necessaris per publicar a Internet una base de dades creada amb Microsoft Access utilitzant la tecnologia ASP. Es parteix d'un exemple de base de dades creada per a controlar el procés d'adquisicions i es van resseguint, en forma ...
Rodríguez-Gairín, Josep-Manuel
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2000 Es descriuen els passos necessaris per publicar a Internet una base de dades creada amb Microsoft Access utilitzant la tecnologia ASP. Es parteix d'un exemple de base de dades creada per a controlar el procés d'adquisicions i es van resseguint, en forma ...
Rodríguez-Gairín, Josep-Manuel
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source