Results 51 to 60 of about 2,576,022 (264)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

INSTITUTIONAL PARADOXES OF INFORMATIZATION OF STATE AND MUNICIPAL GOVERNANCE IN MODERN RUSSIA

Russian Journal of Economics and Law, 2015
Objective: to show that the informatization of state and municipal governance in modern Russia should be aimed directly at reducing costs and improving productivity of the state and municipal authorities, and not at the achievement of indirect ...
N. V. Lukashov
doaj  

Document Management in Local Governments: The Principle of Organization and Optimization Methods on the Example of the Municipal District Administration

RUDN Journal of Public Administration
The article discusses the organization of work with documents in a local government body on the example of the administration of the Perelyubsky municipal district of the Saratov region.
Artyom A. Berkaliev, Darya N. Kovaleva
doaj   +1 more source

Diagnostics of the Enterprise Participation in Electronic Public Procurement: the Aspect of Logistics Management [PDF]

Problemi Ekonomiki, 2017
The aim of the article is to formulate and develop the theoretical and methodological foundations for the functioning of the electronic public procurement system in the logistic environment and develop an approach to determining the level of enterprise ...
Klyuvak Oksana V.
doaj  

Patrimonial bureaus procedures of the landlord farms in Russia during the second half of the 19th - early 20th century: the documentation structure

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2019
The relevance of the study lies in the insufficient development in the domestic historiography of the problem of patrimonial bureau procedures in landlords farms, and the need to consider the features of a large market economy with the possibility of ...
R. M. Zhitin, A. G. Topilskiy
doaj   +1 more source

Optimization Problems of Document Processing Management

Кібернетика та комп'ютерні технології, 2020
Introduction. The use of various cloud services is becoming an integral part of modern life. At the same time, the owners of such services usually are not going to inform users with the theoretical foundations of the deployment and provision of these ...
Yu.P. Laptin, T.O. Bardadym, A.V. Lefterov   +2 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

An Assessment of the Colorado Refugee Services Program With Recommendations for Improvement [PDF]

, 2005
Summarizes findings on the structure and services of the state's refugee resettlement program from document reviews, interviews, and focus group discussions.

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