Results 51 to 60 of about 4,153,024 (248)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Preservação de documentos arquivísticos digitais: reflexões sobre as estratégias de encapsulamento │ Preservation of digital archival documents: reflections on the strategies of encapsulation

Liinc em Revista, 2015
RESUMO Os constantes avanços das tecnologias da informação ocasionaram mudanças no que tange à gênese do documento arquivístico, considerado objeto de estudo da arquivologia.
Daniel Flores, Henrique Machado dos Santos   +1 more
doaj   +1 more source

Preservation Working Group Survey 2013-5-04

, 2013
This document presents results from the International Internet Preservation Consortium Preservation Working Group Survey on web archiving and digital preservation ...
International Internet Preservation Consortium. Preservation Working Group
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Digital preservation and LOCKSS networks

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2023
Miguel Ángel Márdero Arellano
doaj   +1 more source

2016-2020 Consortium Agreement of the International Internet Preservation Consortium

, 2016
This document contains the consortium agreement of the International Internet Preservation Consortium.
International Internet Preservation Consortium
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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

ERPANET OAIS Training Report

, 2003
The training seminar provided accessible and transferable training to participants on the OAIS model itself, its functionalities, and its wider potential applications. Participants gained familiarity with the main features of the model, and examined some

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