Results 51 to 60 of about 37,588 (256)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Investigación Bibliotecológica: Archivonomía, Bibliotecología e Información, 2012 Se analiza la evolución de los principales proyectos de preservación documental digital a nivel mundial, destacando sus premisas y elementos más relevantes, así como diversas estrategias que se han desarrollado para su posible preservación.
Juan Voutssás M.
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Revistes electròniques, comunicació científica i biblioteques
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2001 El recent auge de les revistes científiques electròniques va tenir els seus inicis quan les biblioteques van començar a tenir accés a la World Wide Web (WWW) a mitjan dels noranta.
Keefer, Alice
doaj
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Electronic journals, scholarly communication and libraries
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2001 El recent auge de les revistes científiques electròniques va tenir els seus inicis quan les biblioteques van començar a tenir accés a la World Wide Web (WWW) a mitjan dels noranta.
Keefer, Alice
doaj
Revista Eletrônica do Curso de Direito da UFSM, 2017 The management of documents produced by the Judiciary in the exercise of its judicial function constitutes a constitutional duty of the judicial public administration, since custody and access to these documents are important points of connection between
Elaine Harzheim Macedo +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source