Results 101 to 110 of about 2,571,116 (290)

ENHANCING ADMINISTRATIVE SERVICES THROUGH DOCUMENT MODELS [PDF]

open access: yes
As the European Service Directive has already been enforced, a new challenge is to ensure a fully interoperable e-Government environment at the European level.
Andrei TOMA   +2 more
core  

Enthusiasm Trust and Community Space Challenge: impact evaluation [PDF]

open access: yes, 2012
The aims of research were:- • To build a body of evidence of impact regarding environmental volunteering services on young people, and on the community • To provide an overview of the types of young people who have participated in the past • To document ...
Hutchinson, Jo, Moore, Nicki
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

OA Document Type Definitions

open access: yes, 2005
Kay Ethier and Scott Abel, Freely available structures: XML Document Type Definitions you can use today, Free Software Magazine, July 2005. Excerpt: The the article then describes and links to five OA DTD's. One that it doesn't mention is the NCBI Archiving and Interchange DTD.
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Study on the characteristics and mechanism of antibiotic pollution in different aquifers

open access: yesShuiwen dizhi gongcheng dizhi
The risk posed by antibiotics in various aquifers has attracted wide attention. This study investigated the pollution characteristics and controlling factors of antibiotics in different types of aquifers, and identified the indicator factors of ...
Jialin WANG, Jinwei PAN, Fei LIU
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Discrete series representations and K multiplicities for U(p,q). User's guide

open access: yes, 2010
This document is a companion for the Maple program : Discrete series and K-types for U(p,q) available on:http://www.math.jussieu.fr/~vergne We explain an algorithm to compute the multiplicities of an irreducible representation of U(p)x U(q) in a discrete
Baldoni, Velleda, Vergne, Michele
core  

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