Results 111 to 120 of about 2,583,085 (297)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
ENHANCING ADMINISTRATIVE SERVICES THROUGH DOCUMENT MODELS [PDF]
As the European Service Directive has already been enforced, a new challenge is to ensure a fully interoperable e-Government environment at the European level.
Andrei TOMA +2 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Coping with Water Scarcity: What Role for Biotechnologies? [PDF]
, 2008 At a conference of the FAO Biotechnology Forum in 2007, 78 participants from 24 countries offered their views on agricultural biotechnologies and water scarcity, addressing the pros and cons of various methods and their potential application.
Andrea Sonnino +3 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
DOCUMENT MANAGEMENT IN CONTEXT OF COLLABORATIVE SYSTEMS [PDF]
In this paper we will present the implementation aspects of a document management application, meant to administrate different types of formats. We propose an application which provides full functionality for accessing information, taking into account ...
Costin Aurelian-Răzvan +2 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Module-based Multimedia Document Model: Basic Principles and Software Architecture
Моделирование и анализ информационных систем, 2011 This paper describes an approach to multimedia documents modeling. The approach allows a non-programming user to compose pages from objects of different types (blocks) and to install new types of objects (modules) made by third-party programmers.
V. I. Janvarev
doaj