Results 121 to 130 of about 599,620 (310)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Boletín Información Documental Vol.1 No. 1 = Documental Information Newsletter Vol. 1 No. 1 [PDF]

open access: yes, 2008
First number of the first volume of the Documental Information Bulletin of the Center of Research in Documental Information at the Faculty of Philosophy and Letters of the Nuevo Leon Autonomous University ...
Muela-Meza, Zapopan Martín   +1 more
core  

Nueva Colección Documental de la Independencia del Perú. La Rebelión de Túpac Amaru II. Volumen 2 [PDF]

open access: yes
Este es el segundo de siete volúmenes de la obra La rebelión de Túpac Amaru II, la cual forma parte de la “Nueva Colección Documental de la Independencia del Perú”, una iniciativa para celebrar el Bicentenario de la Independencia del Perú.
Huerto Vizcarra, Héctor
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Formato Acta de Eliminación Documental

open access: yes, 2015
Formato Acta de Eliminación Documental - Universidad Militar Nueva ...
Universidad Militar Nueva Granada
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Retrato de cineasta pintando en el estudio: relaciones entre pintura y cine en David Lynch: The Art Life (2016)

open access: yesMillars. Espai i Història, 2018
David Lynch: The Art life (2016) es un documental que supone un interesantísimo acercamiento a una figura tan fascinante como polifacética: David Lynch. Este film indaga en las primeras décadas de vida de quien, empezando su periplo artístico como pintor,
Ángel Justo Estebaranz
doaj  

Tabla de Retención Documental - TRD

open access: yes, 2018
Tablas de Retención Documental - Universidad Militar Nueva ...
Universidad Militar Nueva Granada
core  

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