Results 61 to 70 of about 371,509 (298)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Palliative care: A proposal for undergraduate education in Medicine

open access: yesRevista Brasileira de Geriatria e Gerontologia, 2018
Objective: to propose essential competencies for the teaching of palliative care on undergraduate Medicine courses. Method: a documentary analysis of the literature on general competencies in palliative care was initially carried out, to construct a ...
Gustavo Henrique de Oliveira Caldas   +2 more
doaj   +2 more sources

Cinema of poverty: Independence and simplicity in an age of abundance and complexity [PDF]

open access: yes, 2010
Over the past 25 years of writing, producing and directing, my aspirations as a creative artist in film have shifted from a paradigm in which the scale and scope of financial and human resources shaped not only the creative intentions of a project, but ...
Knudsen, E
core  

The Convergence Review and the future of Australian content regulation [PDF]

open access: yes, 2012
This article examines the place of Australian and local content regulation in the new media policy framework proposed by the Convergence Review. It outlines the history of Australian content regulation and the existing policy framework, before going on ...
Goldsmith, Ben, Thomas, Julian
core   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Documentary Filmmakers' Statement of Best Practices in Fair Use [PDF]

open access: yes, 2006
Clarifies common misunderstandings about fair use doctrine and presents a formal guideline, organized around four classes of copyright situations that documentary filmmakers and artists confront regularly in practice, for determining fair ...

core  

Broadcasting graphic war violence: the moral face of Channel 4 [PDF]

open access: yes, 2013
Drawing on empirical data from Channel 4 (C4) regarding the broadcasting of violent war imagery, and positioned within Goffman’s notion of the interaction ritual (1959, 1967), this article investigates how C4 negotiate potentially competing commercial ...
BBC2   +24 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

THE IMPORTANCE OF THE TOWN GALATZ IN THE ECONOMIC DEVELOPMENT OF MOLDAVIA DURING THE FIRST HALF OF THE NINETEENTH CENTURY

open access: yesJournal of Industrial Design and Engineering Graphics, 2014
The purpose of this paper is to present the activity of foreigners in the port city of Galatz, during the first half of the 19th century. Consulted material included documentary sources, monographs, and historical synthesis.
CHEŞCU Ana-Maria
doaj  

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