Results 71 to 80 of about 13,578,871 (275)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Review: Ralf Bohnsack, Aglaja Przyborski & Burkhard Schäffer (Eds.) (2010). Das Gruppendiskussionsverfahren in der Forschungspraxis [The Group Discussion Technique in Research Practice]

Forum: Qualitative Social Research, 2011
This edited volume comprises a range of studies that have employed a group discussion technique in combination with a specific strategy for reconstructive social research—the so-called documentary method.
Diana Schmidt-Pfister
doaj  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Review: Aglaja Przyborski & Monika Wohlrab-Sahr (2009). Qualitative Sozialforschung. Ein Arbeitsbuch [Qualitative Research. A Textbook]

Forum: Qualitative Social Research, 2010
The introductory textbook "Qualitative Sozialforschung [Qualitative Research]" by PRZYBORSKI and WOHLRAB-SAHR is addressed to students and teachers alike interested in methodology and methods.
Oliver Berli
doaj  

Scientific Competence in Undergraduate Medical Education: Professional Orientations of Physiology Educators

International Medical Education
Introduction: Scientific Competence (SC) is a central objective in medical education, but its conceptualization remains insufficiently differentiated, particularly regarding the relationship between evidence use and participation in scientific knowledge ...
Alexander Peter Schwoerer, Christian Albert, Katrin Werwick, Christoffer Krug, Holger Buggenhagen, Rüdiger Christian Braun-Dullaeus, Philipp Stieger   +6 more
doaj   +1 more source

Exploring Intersectional Perspectives with the Documentary Method

Sozialer Sinn
Zusammenfassung In diesem Beitrag wird untersucht, wie der intersektionaler Ansatz mit der dokumentarischen Methode fruchtbar kombiniert werden kann. Unsere Forschung beschäftigt sich mit Geflüchteten, die aufgrund von Fluchtmigration von ihren Familien getrennt wurden.
Emmanuel Ndahayo, Karin Schittenhelm
openaire   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Semiotic Documentary Measurement by Pavel Faryenyuk

Вісник Київського національного університету культури і мистецтв. Серія: Аудіовізуальне мистецтво і виробництво, 2018
The purpose of the research is to reveal the construction of the system of images and signs in the documentary films of the famous Ukrainian film director Pavel Nikolaevich Faryenyuk.
Оlena Moskalenko-Vysotska
doaj   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Comparative Research on Highly Skilled Migrants. Can Qualitative Interviews Be Used in Order to Reconstruct a Class Position?

Forum: Qualitative Social Research, 2006
BOURDIEU's theoretical concept of "classes on paper" is based on the nation-state frame. In order to include the social position of migrants, who live and work in more than one nation-state, a concept of social and structural transnationalisation is ...
Anja Weiß
doaj