Results 131 to 140 of about 3,148,880 (368)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Notes Documentaires et Études, n° 918 (série française. - CXCII). La lecture publique en France [PDF]

« Document numérisé pour l\u27ENSSIB » - Réalisé par la Direction de la documentation, ce document officiel s\u27adresse aux professionnels. Dans le cadre de ce corpus, il s\u27inscrit dans un ensemble de trois brochures de "Notes et Études Documentaires"
Direction de la Documentation
core   +1 more source

Submission Guidelines, 1(1)

Language Documentation & Conservation, 2007
Language Documentation & Conservation
doaj   +1 more source

Implicit Is Not Enough: Explicitly Enforcing Anatomical Priors inside Landmark Localization Models

Bioengineering
The task of localizing distinct anatomical structures in medical image data is an essential prerequisite for several medical applications, such as treatment planning in orthodontics, bone-age estimation, or initialization of segmentation methods in ...
Simon Johannes Joham, Arnela Hadzic, Martin Urschler   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Wiring harnesses documented by punched-card technique [PDF]

, 1970
Cards representing a connector are punched, sorted, and then used to printout wiring documentation for that connector. When wiring changes are made, new cards are punched and the wiring documentation is reprinted to reflect the latest ...
Hicks, W. W., Kloezeman, W. G.
core   +1 more source

Editorial Board, 1(1)

Language Documentation & Conservation, 2007
Language Documentation & Conservation
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Enterprise Data Bank Documentation [PDF]

Farm Management,
Langemeier, Larry N.
core   +1 more source

Knowledge and Practice of Tabriz Teaching Hospitals’ Nurses Regarding Nursing Documentation

, 2012
Madineh Jasemi, Vahid Zamanzadeh, Azad Rahmani, Alireza Mohajjel, Fahime Alsadathoseini   +4 more
openalex   +1 more source