Results 171 to 180 of about 2,660,577 (345)
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
A First-Person Theory of Documentation [PDF]
, 2019 Purpose To first articulate and then illustrate a descriptive theoretical model of documentation (i.e., document creation) suitable for analysis of the experiential, first-person perspective.
Gorichanaz, Tim
core
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Language Documentation & Conservation, 2007 Language Documentation & Conservation
doaj +1 more source
Large Language Models for Clinical Text Cleansing Enhance Medical Concept Normalization
IEEE AccessMost clinical information is only available as free text. Large language models (LLMs) are increasingly applied to clinical data to streamline communication, enhance the accuracy of clinical documentation, and ultimately improve healthcare delivery. This
Akhila Abdulnazar +3 more
doaj +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Clustering Document Parts: Detecting and Characterizing Influence Campaigns from Documents [PDF]
arXivWe propose a novel clustering pipeline to detect and characterize influence campaigns from documents. This approach clusters parts of document, detects clusters that likely reflect an influence campaign, and then identifies documents linked to an influence campaign via their association with the high-influence clusters.
arxiv