Results 11 to 20 of about 4,111 (142)

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Prevalence of high‐risk plasma p‐tau217 levels and 5‐year transition of risk status in 70‐year‐olds

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION High‐risk plasma p‐tau217 levels predict amyloid‐β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population. METHODS Participants from the Gothenburg H70 Birth Cohort Study in Sweden were examined (n = 1157) and re‐examined after 5–7 years (n = 771).
Anna Dittrich, Burak Arslan, Tobias Skillbäck, Lina Rydén, Hlin Kvartsberg, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Silke Kern, Ingmar Skoog   +9 more
wiley   +1 more source

Tendência da mortalidade por doença cerebrovascular no Estado de São Paulo: 1970 a 1989

Arquivos de Neuro-Psiquiatria, 1993
OBJETIVO: estudo descritivo da mortalidade proporcional e por coeficientes da doença cerebrovascular (DCbV) na população adulta (20 anos e mais) do Estado de São Paulo.
Paulo Andrade Lotufo, Cecília Amaro de Lolio   +1 more
doaj   +1 more source

Disfunção endotelial venosa em pacientes com doença de Chagas sem insuficiência cardíaca Venous endothelial dysfunction in Chagas' disease patients without heart failure

Arquivos Brasileiros de Cardiologia, 2006
OBJETIVO: Analisar a função endotelial venosa em pacientes chagásicos sem insuficiência cardíaca. MÉTODOS: O grupo Chagas (G1) foi composto por quatorze mulheres e dois homens com idade de 46 ± 2,7 anos, e o grupo controle (G0), por sete mulheres ...
Rodrigo Della Méa Plentz, Maria Claudia Irigoyen, Andreia Simone Muller, Dulce Elena Casarini, Marcelo Custodio Rubira, Heitor Moreno Junior, Charles Mady, Bárbara Maria Ianni, Eduardo Moacir Krieger, Fernanda Consolim-Colombo   +9 more
doaj   +1 more source

Frailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature

Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 854-867, March 2026.
ABSTRACT Introduction Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...
Miguel German Borda, Luis Carlos Venegas‐Sanabria, Marco Canevelli, Francesco Landi, Salomón Páez‐García, Kevin O'Hara‐Veintimilla, Lindsay Wallace, Kenneth Rockwood, Tommy Cederholm, Gustavo Duque, Mario Ulises Pérez‐Zepeda, Dag Aarsland   +11 more
wiley   +1 more source

Doenças crônicas não transmissíveis e outras condições nutricionais na covid-19: potenciais mecanismos e implicações

Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2022
Introdução e objetivo: A presente revisão tem como objetivo integrar e discutir estudos que relacionam a COVID-19 com doenças crônicas não transmissíveis (DCNT) e outras condições nutricionais, buscando compreender os mecanismos patológicos envolvidos ...
Rafaela Corrêa Pereira, Andrezza Fernanda Santiago, Juciane de Abreu Ribeiro Pereira, Michel Cardoso de Angelis-Pereira   +3 more
doaj  

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 354-366, February 2026.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Microcirculation in obesity: an unexplored domain

Anais da Academia Brasileira de Ciências, 2007
Obesity is traditionally linked to diabetes and cardiovascular diseases. Very recent experimental, clinical and epidemiological, sometimes provocative, data challenge this automaticity by showing that not the amount but the distribution of fat is the ...
Nicolas Wiernsperger, Pierre Nivoit, Eliete Bouskela   +2 more
doaj   +1 more source

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The sortilin‐related receptor (SORL1) directs APP and Aβ trafficking within the retromer pathway. Cleavage at the cell surface releases soluble SORL1 (sSORL1) into cerebrospinal fluid (CSF). We examined whether CSF‐sSORL1 can serve as an in vivo marker of genetically impaired SORL1.
Matthijs W. J. de Waal, Sven J. van der Lee, Melanie Lunding, Lynn Boonkamp, Nolan Barrett, Giulia Monti, Anne Mette G. Jensen, Christian B. Vaegter, Jan Raska, Sona Cesnarikova, Jiri Sedmik, Calvin Trieu, Marjan M. Weiss, Rosalina van Spaendonk, Lisa Vermunt, Georgii Ozhegov, Niccolo Tesi, Marc Hulsman, Dovile Januliene, Arne Moller, Dasa Bohaciakova, Wiesje M. van der Flier, Olav M. Andersen, Charlotte E. Teunissen, Henne Holstege   +24 more
wiley   +1 more source

Rastreamento da pressão arterial em uma cidade do interior de Minas Gerais

Em Extensão, 2019
Este relato tem como objetivo descrever a experiência e a importância de um projeto de extensão desenvolvido por alunos e professores da Universidade Federal de Uberlândia em parceira com o Programa de Rastreamento da Pressão Arterial no Brasil em ...
Willian Alves Fonseca, Patricia Magnabosco, Omar Pereira Almeida Neto, Valéria Nasser Figueiredo   +3 more
doaj   +1 more source