Results 21 to 30 of about 4,111 (142)

Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron‐to‐neuron transmission along its projections. The lower integrity of the LC‐EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains ...
Yuliya Patsyuk, Maxime Van Egroo, Elise Beckers, Elouise A. Koops, Nicholas J. Ashton, Shorena Janelidze, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Benedikt A. Poser, Heidi I. L. Jacobs   +10 more
wiley   +1 more source

Programa domiciliar de exercícios: efeitos de curto prazo sobre a aptidão física e pressão arterial de indivíduos hipertensos Home exercise program: short term effects on physical aptitude and blood pressure in hypertensive individuals

Arquivos Brasileiros de Cardiologia, 2005
OBJETIVO: Observar a influência de quatro meses de um programa domiciliar não-supervisionado de exercícios sobre a pressão arterial (PA) e aptidão física em hipertensos.
Paulo de Tarso Veras Farinatti, Ricardo Brandão de Oliveira, Vivian Liane Mattos Pinto, Walace David Monteiro, Emílio Francischetti   +4 more
doaj   +1 more source

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Osmar Vieira Ramires Júnior, Gustavo Ricardo Krupp Prauchner, Alessandra Schmitt Rieder, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela T. S. Wyse   +5 more
wiley   +1 more source

Lupus eritematoso sistêmico: novo fator de risco para aterosclerose? Is systemic lupus erithematosus a new risk factor for atherosclerosis?

Arquivos Brasileiros de Cardiologia, 2006
OBJETIVO: Avaliar a prevalência de eventos cardiovasculares (ECV) secundários à aterosclerose em pacientes com lupus eritematoso sistêmico (LES) e correlacioná-los aos tradicionais fatores de risco, tempo de doença e drogas utilizadas na terapia. MÉTODOS:
Beatriz Funayama Alvarenga Freire, Rogério Cardoso da Silva, Alexandre Todorovic Fabro, Daniela Cristina dos Santos   +3 more
doaj   +1 more source

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, Volume 103, Issue 7, Page e511-e523, November 2025.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source

Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double‐Blind Trial

Molecular Nutrition &Food Research, Volume 69, Issue 17, September 2025.
This study explored how a 90‐day nutraceutical blend with prebiotics, minerals, and silymarin affects the gut‐brain axis in overweight adults. Results showed improved gut microbiota, reduced inflammation, and better sleep, mood, and quality of life, suggesting a strong link between gut health and mental well‐being.
Aline Boveto Santamarina, Victor Nehmi Filho, Jéssica Alves de Freitas, Lucas Augusto Moysés Franco, Roberta Cristina Martins, Joyce Vanessa Fonseca, José Antônio Orellana Turri, Mariana Tedesco Hufnagel, Daniel Pecoraro Demarque, Bruna Fernanda Rio Branco da Silva, Arianne Fagotti Gusmão, Eloísa Helena Ribeiro Olivieri, Erica de Souza, Esther Alves de Souza, José Pinhata Otoch, Ana Flávia Marçal Pessoa   +15 more
wiley   +1 more source

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia‐specific perspectives

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease‐modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment‐induced changes in ...
Takeshi Iwatsubo, Reisa A. Sperling, Alicia Algeciras‐Schimnich, Hidenori Arai, Anna M. Barron, Tammie L. S. Benzinger, Maria C. Carrillo, Christopher Chen, Seong Hye Choi, Igor C. Fontana, Jonathan Graff‐Radford, Joshua D. Grill, Judith Heidebrink, Chaur‐Jong Hu, Ryoko Ihara, Takeshi Ikeuchi, Atsushi Iwata, Fanny C. F. Ip, Fasihah Irfani Fitri, Clifford R. Jack Jr., Jee Hyang Jeong, Jianping Jia, Nagaendran Kandiah, SangYun Kim, Hisatomo Kowa, Renaud La Joie, Yoshiki Niimi, Ryoji Noritake, Ozioma C. Okonkwo, Sebastian Palmqvist, Michael S. Rafii, Rema Raman, Yong Shen, Tanya Simuni, Heather M. Snyder, Orapitchaya Sriwannopas, Luke E. Stoeckel, Wiesje M. van der Flier, Huali Wang, Donna M. Wilcock, Henrik Zetterberg, Jin Zhou, Simin Mahinrad, Claire E. Sexton   +43 more
wiley   +1 more source

Avaliação dos efeitos a curto prazo de programas de conscientização e de terapia com pravastatina em indivíduos de alto risco para doença cardiovascular provenientes de consultórios particulares The evaluation of short term effects of awareness programs and pravastatin therapy on subjects from private clinics at high risk for cardiovascular disease

Arquivos Brasileiros de Cardiologia, 1997
OBJETIVO: Avaliar a eficácia de programas de conscientização (PC) sobre o controle de fatores de risco (FR) para doença cardiovascular (DCV). MÉTODOS: Pacientes hipercolesterolêmicos de alto risco para DCV foram divididos em 2 grupos durante 16 semanas ...
Raul D. Santos, Luiz O. do Nascimento, Raul C. Maranhão   +2 more
doaj   +1 more source

Ultrafast Imaging of Physiological Brain Pulsations With Magnetic Resonance Encephalography—From Noise to Predictive Clinical Biomarker

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
Human brain pulsations shown in this picture drive both blood and CSF flow. These pulsations can now be accurately detected with ultrafast MREG imaging. The ultrafast imaging offers early detection of abnormal brain pulsations that can precede tissue degeneration in Alzheimer's disease or predict mortality in brain lymphoma treatment. ABSTRACT Over the
Vesa Kiviniemi, Heta Helakari, Lauri Raitamaa, Niko Huotari, Zalan Rajna, Matti Järvelä, Ahmed Elabasy, Johanna Tuunanen, Valter Poltojainen, Tommi Väyrynen, Timo Tuovinen, Janne Kananen, Vesa Korhonen   +12 more
wiley   +1 more source

Short‐ and Long‐Term Effect of Multidomain Lifestyle Intervention on Frailty: Post Hoc Analysis of an RCT

Journal of the American Geriatrics Society, Volume 73, Issue 8, Page 2457-2465, August 2025.
A Sankey diagram illustrating the flow of participants from baseline frailty status to each follow‐up assessment. Data represents numbers of participants observed in each group. ABSTRACT Background The prevalence of frailty is increasing as the population ages. Lifestyle interventions have shown potential in frailty prevention.
Johanna Pöyhönen, Hanna‐Maria Roitto, Jenni Lehtisalo, Esko Levälahti, Timo Strandberg, Miia Kivipelto, Jenni Kulmala, Riitta Antikainen, Hilkka Soininen, Jaakko Tuomilehto, Tiina Laatikainen, Tiia Ngandu   +11 more
wiley   +1 more source