Results 31 to 40 of about 824 (137)

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Osmar Vieira Ramires Júnior, Gustavo Ricardo Krupp Prauchner, Alessandra Schmitt Rieder, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela T. S. Wyse   +5 more
wiley   +1 more source

Etiopatogenia da doença de Parkinson: a revolução do M.P.T.P.

Acta Médica Portuguesa, 1988
Faz-se a apresentação do modelo experimental da doença de Parkinson, desenvolvido a partir do momentoem que se constatou que um derivado sintético da heroína — o MPTP — provoca nos humanos, um quadro semelhante ao da doença idiopática.Discute-se o ...
Cristina Sampaio, A. Castro Caldas
doaj   +1 more source

Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis of dementia (CDR < 1) with T1w‐MRI and amyloid‐PET, including 622 with longitudinal data (3.66 ± 1.78 years).
Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Federico Masserini, Mara ten Kate, Lyduine E. Collij, Giuseppe Pontillo, Emma S. Luckett, Alle Meije Wink, Henk JMM Mutsaerts, Tiago Gil Oliveira, Daniele Altomare, Mercè Boada, Anouk den Braber, Cindy Birck, Christopher Buckley, Gill Farrar, Wiesje van der Flier, Giovanni B. Frisoni, Rossella Gismondi, Juan Domingo Gispert, Bernard J. Hanseeuw, Frank Jessen, Marta Marquié, Anja Mett, Craig Ritchie, Gemma Salvadó, Michael Schöll, Mahnaz Shekari, Andrew W. Stephens, Betty M. Tijms, David Vállez García, Rik Vandenberghe, Pieter Jelle Visser, Luca Roccatagliata, Neil P. Oxtoby, Matteo Pardini, Frederik Barkhof   +37 more
wiley   +1 more source

Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders

Journal of Neuropsychology, Volume 19, Issue 3, Page 603-618, September 2025.
Abstract Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments in NCDs seldom include tests exploring social cognitive skills. In 2022, we launched the SIGNATURE initiative to optimize socio‐cognitive assessment in NCDs.
Chiara Cerami, Marina Boccardi, Claudia Meli, Andrea Panzavolta, Giulia Funghi, Cristina Festari, Stefano F. Cappa, Thanos Chatzikostopoulos, Christian Chicherio, Florencia Clarens, Fabricio Ferreira de Oliveira, Francesco Di Lorenzo, Marco Filardi, Agustin Ibanez, Nicola Girtler, Thibaud Lebouvier, Giancarlo Logroscino, Antonella Luca, Sarah E. MacPherson, Jordi A. Matias‐Guiu, Tommaso Piccoli, Olivier Piguet, Simone Pomati, Mirella Russo, Leonardo Sacco, Ann‐Katrin Schild, Stefano L. Sensi, Steven D. Shirk, Marc Sollberger, Miguel Tábuas‐Pereira, Magda Tsolaki, Esther van den Berg, Maxime Bertoux, Fiona Kumfor, Jan Van den Stock, Kathleen A. Welsh‐Bohmer, Alessandra Dodich, on behalf of the SIGNATURE initiative   +37 more
wiley   +1 more source

Doença de Parkinson: Alterações Funcionais e Potencial Aplicação do Método Pilates [PDF]

Geriatrics, Gerontology and Aging
A doença de Parkinson é uma desordem neurodegenerativa que compromete os neurônios dopaminérgicos da substância negra, levando a déficit de dopamina no corpo estriado, que dificulta a modulação do movimento.
Maria do Carmo Correia de Lima, Adriana Macedo de Miranda, Paula Prestrelo Costa Martins, Etiene Oliveira da Silva Fittipaldi   +3 more
doaj  

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia‐specific perspectives

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease‐modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment‐induced changes in ...
Takeshi Iwatsubo, Reisa A. Sperling, Alicia Algeciras‐Schimnich, Hidenori Arai, Anna M. Barron, Tammie L. S. Benzinger, Maria C. Carrillo, Christopher Chen, Seong Hye Choi, Igor C. Fontana, Jonathan Graff‐Radford, Joshua D. Grill, Judith Heidebrink, Chaur‐Jong Hu, Ryoko Ihara, Takeshi Ikeuchi, Atsushi Iwata, Fanny C. F. Ip, Fasihah Irfani Fitri, Clifford R. Jack Jr., Jee Hyang Jeong, Jianping Jia, Nagaendran Kandiah, SangYun Kim, Hisatomo Kowa, Renaud La Joie, Yoshiki Niimi, Ryoji Noritake, Ozioma C. Okonkwo, Sebastian Palmqvist, Michael S. Rafii, Rema Raman, Yong Shen, Tanya Simuni, Heather M. Snyder, Orapitchaya Sriwannopas, Luke E. Stoeckel, Wiesje M. van der Flier, Huali Wang, Donna M. Wilcock, Henrik Zetterberg, Jin Zhou, Simin Mahinrad, Claire E. Sexton   +43 more
wiley   +1 more source

Establishing a Research Agenda for Physiotherapy in Portugal: A Delphi Study

Physiotherapy Research International, Volume 30, Issue 3, July 2025.
ABSTRACT Background As physiotherapy research advances, identifying knowledge gaps and setting priorities is crucial for enhancing its efficiency in national and international collaborations. This study aimed to establish a physiotherapy research agenda in Portugal by integrating perspectives from physiotherapists and users of physiotherapy services ...
Isa Silva, Sara Souto‐Miranda, Fernando Ribeiro, Diogo Pires, Maria José Coutinho, Nuno Cordeiro, Eduardo Cruz, Cristina Jácome   +7 more
wiley   +1 more source

Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's disease and related dementias (ADRD) by integrating whole genome sequencing (WGS) with other genetic, phenotypic, and harmonized datasets from diverse populations. METHODS The Genome Center for Alzheimer'
Yuk Yee Leung, Wan‐Ping Lee, Amanda B. Kuzma, Heather Nicaretta, Otto Valladares, Prabhakaran Gangadharan, Liming Qu, Yi Zhao, Youli Ren, Po‐Liang Cheng, Pavel P. Kuksa, Hui Wang, Heather White, Zivadin Katanic, Lauren Bass, Naveen Saravanan, Emily Greenfest‐Allen, Maureen Kirsch, Laura Cantwell, Taha Iqbal, Nicholas R. Wheeler, John J. Farrell, Congcong Zhu, Shannon L. Turner, Tamil I. Gunasekaran, Pedro R. Mena, Yumi Jin, Luke Carter, Alzheimer's Disease Sequencing Project, Xiaoling Zhang, Badri N. Vardarajan, Arthur Toga, Michael Cuccaro, Timothy J. Hohman, William S. Bush, Adam C. Naj, Eden Martin, Clifton L. Dalgard, Brian W. Kunkle, Lindsay A. Farrer, Richard P. Mayeux, Jonathan L. Haines, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, Li‐San Wang   +44 more
wiley   +1 more source

Grupo de apoio às pessoas com Doença de Parkinson e seus familiares

Extensio: Revista Eletrônica de Extensão, 2016
O presente estudo tem como objetivo descrever a experiência do projeto de extensão – Grupo de apoio às pessoas com doença de Parkinson e seus familiares no âmbito da Universidade Federal de Santa Catarina. Esse projeto tem como metodologia de trabalho a
Angela Maria Alvarez, Lucia Isako Takasi Gonçalves, Jordelina Schier, Karina Silvieira de Almeida Hammerschmidt, Bruna Caroline de Souza, Rafaela Vivian Valcarenghi   +5 more
doaj   +1 more source

Alzheimer's disease traits in Parkinson's disease without α‐synuclein seeding

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION The α‐synuclein (αSyn) seed amplification assay (αSyn‐SAA) is an accurate tool to detect αSyn seeds in patients with Parkinson's disease (PD). However, a minority of clinically diagnosed PD patients are negative for αSyn. METHODS The αSyn‐SAA was performed in cerebrospinal fluid (CSF) of individuals with PD (n = 93), multiple ...
Bárbara Fernandes Gomes, Carly M. Farris, Yihua Ma, Luis Concha‐Marambio, Johanna Nilsson, Karin Forsberg, Russ Lebovitz, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, David Bäckström   +10 more
wiley   +1 more source