Results 1 to 10 of about 602 (109)

Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs [PDF]

Scientific Reports
Parasitic worm infections impose a significant public health burden, affecting over 2 billion people, particularly in low-income regions. The limited efficacy of current treatments highlights the urgent need for new anthelmintic agents.
Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes   +9 more
doaj   +2 more sources

Discovery of clocinizine as a potential oral drug against Schistosoma mansoni infection [PDF]

Scientific Reports
Schistosomiasis, a disease caused by parasitic worms, imposes a significant global health burden, affecting over 240 million people, particularly in low-income regions.
Thalitta Castro, Thainá R. Teixeira, Mariana Siegl, Flávia B. Lopes, Maria Cristina C. Espírito-Santo, João Paulo S. Fernandes, Josué de Moraes   +6 more
doaj   +2 more sources

EDBD—3,6-Epidioxy-1,10-Bisaboladiene—An Endoperoxide Sesquiterpene Obtained from Drimys brasiliensis (Winteraceae) Exhibited Potent Preclinical Efficacy against Schistosoma mansoni Infection [PDF]

Antibiotics
Schistosomiasis, a neglected tropical disease impacting over 250 million individuals globally, remains a major public health challenge due to its prevalence and significant impact on affected communities.
Eric Umehara, Thainá R. Teixeira, Rayssa A. Cajás, Monique C. Amaro, Josué de Moraes, João Henrique G. Lago   +5 more
doaj   +2 more sources

Atomic force microscopy reveals morphological and mechanical properties of schistosoma mansoni tegument [PDF]

Scientific Reports
Schistosoma mansoni, an intravascular parasitic worm and the causative agent of schistosomiasis, relies on its tegument (outer layer) for survival and host interaction. This study explored the morphology and mechanical properties of S.
Adriane M. C. Dantas, Fernanda S. Teixeira, Raissa L. Oblitas, Wagner W. R. Araújo, Monique C. Amaro, Rayssa A. Cajas, Josué de Moraes, Maria C. Salvadori   +7 more
doaj   +2 more sources

In Vitro and In Vivo Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from Drimys brasiliensis Branches [PDF]

Molecules
In the present study, the hexane extract from branches of Drimys brasiliensis (Winteraceae) displayed potent activity against Schistosoma mansoni parasites (100% mortality of the worms at 200 μg/mL). Bioactivity-guided fractionation afforded, in addition
Eric Umehara, Rayssa A. Cajas, Gabriel B. Conceição, Guilherme M. Antar, Adriano D. Andricopulo, Josué de Moraes, João Henrique G. Lago   +6 more
doaj   +2 more sources

Doenças midiaticamente negligenciadas: uma aproximação teórica

Interface: Communication, Health, Education, 2015
Atualmente, a visibilidade midiática se apresenta como condição central para conhecimento público de mazelas sociais. Apesar dos espaços cada vez mais amplos dedicados à saúde nos jornais diários, os critérios para noticiabilidade obedecem à lógica ...
Aline Guio Cavaca, Paulo Roberto Vasconcellos-Silva, Cavaca Aline Guio   +2 more
exaly   +3 more sources

Primitive reflexes in infants with cerebral palsy due to Congenital Zika Syndrome and its relationship with other motor features [PDF]

Frontiers in Pediatrics
BackgroundThe Zika virus outbreak, which occurred from 2015 to 2016 in Brazil, resulted in the birth of neonates with brain malformations arising from Congenital Zika Syndrome (CZS). The characterization of primitive reflexes and their relationships with
Leticia Serra, Leticia Serra, Débora Patrícia Rios, Mino Rios, Breno Lima de Almeida, Kelly de Souza Fernandes, Rita Lucena, Isadora Cristina de Siqueira   +7 more
doaj   +2 more sources

Doenças tropicais negligenciadas: uma nova era de desafios e oportunidades

Quimica Nova, 2013
In an article recently published in Química Nova, entitled "Chemistry Without Borders" ("Química Sem Fronteiras") [Pinto, A. C.; Zucco, C.; Galembeck, F.; Andrade, J. B.; Vieira, P. C. Quim.
Luiz C Dias, Rafael V C Guido, Glaucius Oliva   +2 more
exaly   +3 more sources

Detection of encephalitis-causing viruses reveals predominance of chikungunya virus in the state of Bahia, Brazil

International Journal of Infectious Diseases
Objectives: Encephalitis is a severe neurological syndrome for which herpesvirus and enteroviruses are the most common etiological agents. Arboviruses, a wildly diverse group of pathogens, are also critical epidemiological agents associated with ...
Maria Paula de Souza Sampaio, Mateus Santana do Rosário, Lorena Cunha Martins, Luiza Vieira Luedy Trindade, Marcos Vinicius Lima de Oliveira Francisco, Bernardo Gratival Gouvea Costa, Gessica Almeida Vasconcelos, Italo Andrade Barbosa Lima, Yasmin Santos Freitas Macêdo, Fernanda Maria Lessa Carvalho, Marina Borges Rabelo de Santana, Ricardo Khouri, Hegger Fritsch, Joilson Xavier, Vagner Fonseca, Marta Giovanetti, Arabela Leal e Silva de Mello, Felicidade Mota Pereira, Gubio Soares Campos, Pedro Antonio Pereira de Jesus, Daniel Santana Farias, Murilo Santos de Souza, Adilson Junior Pinto Galvão, Felipe Oliveira Costa, Marcia Carvalho Bessa, Janeusa Rita Leite Primo Chagas, Celia Silvany, Jose Mário Meira Teles, Maricelia Maia de Lima, Tarsis Leonardo Almeida Farias, Tiago Gräf, Isadora Cristina de Siqueira   +31 more
doaj   +2 more sources

Emerging threat of Oropouche virus in Brazil: an urgent call for enhanced surveillance and response [PDF]

Brazilian Journal of Infectious Diseases
Mateus Santana do Rosário, Isadora Cristina de Siqueira   +1 more
doaj   +2 more sources