Results 11 to 20 of about 602 (109)

N-(4-Methoxyphenyl)Pentanamide, a Simplified Derivative of Albendazole, Displays Anthelmintic Properties against the Nematode Toxocara canis

Microbiology Spectrum, 2022
Infections caused by parasitic helminths have enormous health, social, and economic impacts worldwide. The treatment and control of these diseases have been dependent on a limited set of drugs, many of which have become less effective, necessitating the ...
Taís C. Silva, Ana C. Mengarda, Bruna L. Lemes, Susana A. Z. Lescano, Dalete Christine S. Souza, João Henrique G. Lago, Josué de Moraes   +6 more
doaj   +1 more source

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

Journal of Extracellular Vesicles, Volume 10, Issue 10, August 2021., 2021
Abstract Whereas extracellular vesicle (EV) research has become commonplace in different biomedical fields, this field of research is still in its infancy in mycology. Here we provide a robust set of data regarding the structural and compositional aspects of EVs isolated from the fungal pathogenic species Cryptococcus neoformans, C. deneoformans and C.
Juliana Rizzo, Sarah Sze Wah Wong, Anastasia D. Gazi, Frédérique Moyrand, Thibault Chaze, Pierre‐Henri Commere, Sophie Novault, Mariette Matondo, Gérard Péhau‐Arnaudet, Flavia C. G. Reis, Matthijn Vos, Lysangela R. Alves, Robin C. May, Leonardo Nimrichter, Marcio L. Rodrigues, Vishukumar Aimanianda, Guilhem Janbon   +16 more
wiley   +1 more source

Immunopathogenesis of the feline atopic syndrome

Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021
Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell, Frane Banovic, Ralf S. Mueller, Thierry Olivry   +3 more
wiley   +1 more source

H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies

Parasites & Vectors, 2020
Background Schistosomiasis is a socioeconomically devastating parasitic infection afflicting hundreds of millions of people and animals worldwide. It is the most important helminth infection, and its treatment relies solely on the drug praziquantel. Oral
Rogério P. Xavier, Ana C. Mengarda, Marcos P. Silva, Daniel B. Roquini, Maria C. Salvadori, Fernanda S. Teixeira, Pedro L. Pinto, Thiago R. Morais, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Josué de Moraes   +10 more
doaj   +1 more source

Targeting the Schistosoma mansoni nutritional mechanisms to design new antischistosomal compounds

Scientific Reports, 2023
The chemical classes of semicarbazones, thiosemicarbazones, and hydrazones are present in various compounds, each demonstrating diverse biological activities. Extensive studies have revealed their potential as schistosomicidal agents. Thiosemicarbazones,
Thaís F. A. Pavani, Maria E. Cirino, Thainá R. Teixeira, Josué de Moraes, Daniela G. G. Rando   +4 more
doaj   +1 more source

Hospitalizações por doenças tropicais negligenciadas no Piauí, Nordeste do Brasil: custos, tendências temporais e padrões espaciais, 2001-2018

Cadernos de Saúde Pública, 2022
Caracterizar a magnitude das internações hospitalares e custos por doenças tropicais negligenciadas, suas tendências temporais e padrões espaciais no Piauí, Nordeste do Brasil, 2001-2018.
Sheila Paloma de Sousa Brito, Mauricélia da Silveira Lima, Anderson Fuentes Ferreira, Alberto Novaes Ramos Jr.   +3 more
doaj   +1 more source

Assessment of the In Vitro Antischistosomal Activities of the Extracts and Compounds from Solidago Microglossa DC (Asteraceae) and Aristolochia Cymbifera Mart. & Zucc. (Aristolochiaceae)

Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020
Schistosomiasis, caused by helminth flatworms of the genus Schistosoma, is a neglected tropical disease that afflicts over 230 million people worldwide. Currently, treatment is achieved with only one drug, praziquantel (PZQ). In this regard, the roots of Solidago microglossa (Asteraceae) and Aristolochia cymbifera (Aristolochiaceae) are popularly used ...
Poliana da Silva Costa, Ohana Oliveira Zuza da Silva, Danilo de Souza Costa, Lara Aparecida de Oliveira Silva, Priscila de Faria Pinto, Marcos Paulo Nascimento da Silva, Josué de Moraes, Ademar A. Da Silva Filho, Adolfo Andrade-Cetto   +8 more
wiley   +1 more source

Desenvolvimento de novos medicamentos para doenças negligenciadas: uma análise bibliométrica

RECIIS, 2022
Doenças negligenciadas impõem um fardo humano, social e econômico devastador a mais de um bilhão de pessoas em todo o mundo. Embora existam ferramentas para controlar e até mesmo eliminar muitas dessas doenças, novos produtos terapêuticos precisam ...
Paula Teixeira Pinto Ferreira Neto, Taís Rubia dos Santos, Marco Antonio Vargas, Jose Manuel Santos de Varge Maldonado   +3 more
doaj   +1 more source

Inovação em saúde e doenças negligenciadas

Cadernos De Saude Publica, 2006
CARLOS M Morel
exaly   +2 more sources

In Vitro Schistosomicidal Activity of the Alkaloid‐Rich Fraction from Ruta graveolens L. (Rutaceae) and Its Characterization by UPLC‐QTOF‐MS

Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019
Schistosomiasis is a neglected tropical disease that affects million people worldwide, mostly in developing countries. Ruta graveolens (Rutaceae) is a plant used in folk medicine to treat several diseases, including parasitic infections. In this study, we reported the in vitro schistosomicidal activity of the R.
Lara Soares Aleixo de Carvalho, Lucas Sales Queiroz, Ismael José Alves Junior, Ayla das Chagas Almeida, Elaine Soares Coimbra, Priscila de Faria Pinto, Marcos Paulo Nascimento da Silva, Josué De Moraes, Ademar A. Da Silva Filho, Marco Leonti   +9 more
wiley   +1 more source