Results 21 to 30 of about 602 (109)

TGF‐β Polymorphisms Are a Risk Factor for Chagas Disease

Disease Markers, Volume 2018, Issue 1, 2018., 2018
Transforming growth factor β1 (TGF‐β1) is an important mediator in Chagas disease. Furthermore, patients with higher TGF‐β1 serum levels show a worse clinical outcome. Gene polymorphism may account for differences in cytokine production during infectious diseases.
Roberto Rodrigues Ferreira, Fabiana da Silva Madeira, Gabriel Farias Alves, Mayara da Costa Chambela, Eduardo de Oliveira Vaz Curvo, Aline dos Santos Moreira, Renata Almeida de Sá, Leila Mendonça-Lima, Pedro Hernan Cabello, Sabine Bailly, Jean-Jacques Feige, Tania Cremonini Araujo-Jorge, Roberto Magalhães Saraiva, Mariana Caldas Waghabi, Paul Ashwood   +14 more
wiley   +1 more source

Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl‐t‐Butylnitrone Derivative

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
The therapeutic options for Chagas disease are limited and its treatment presents a number of drawbacks including toxicity, drug resistance, and insufficient effectiveness against the chronic stage of the disease. Therefore, new therapeutical options are mandatory.
Mauricio Peixoto Cupello, Francis Monique Saraiva, Pedro Ippolito, Andréia da Silva Fernandes, Rubem Figueiredo Sadoko Menna-Barreto, Debora de Sousa dos Santos Costa, Jessica Isis Oliveira Paula, Paulo Roberto Ribeiro Costa, Natália Pereira Nogueira, Israel Felzenswalb, Ayres Guimarães Dias, Marcia Cristina Paes, Peter Fu   +12 more
wiley   +1 more source

The use of the Ml flow test between newly diagnostic leprosy cases and in-home contacts / O uso do teste Ml flow entre casos de hanseníase recém-diagnosticados e contatos intradomiciliares

Revista de Pesquisa Cuidado é Fundamental Online, 2022
Objetivo: identificar o resultado de teste Ml Flow entre casos de hanseníase recém-diagnosticados e contatos intradomiciliares. Método: estudo transversal, descritivo, com abordagem quantitativa realizado no município de Caxias, Maranhão, Brasil, onde ...
Beatriz Aguiar da Silva, Gleciane Costa de Sousa, Maria Edileuza Soares Moura   +2 more
doaj   +3 more sources

Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties

Frontiers in Chemistry, 2022
Hydroxymethylation is a simple chemical reaction, in which the introduction of the hydroxymethyl group can lead to physical–chemical property changes and offer several therapeutic advantages, contributing to the improved biological activity of drugs ...
Soraya S. Santos, Rodrigo V. Gonzaga, Cauê B. Scarim, Jeanine Giarolla, Marina C. Primi, Chung M. Chin, Chung M. Chin, Elizabeth I. Ferreira   +7 more
doaj   +1 more source

Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms

Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016
Human schistosomiasis, caused by trematode worms of the genus Schistosoma, is one of the most significant neglected tropical diseases, affecting more than 200 million individuals worldwide and praziquantel is the only available drug to treat this disease. Artemisia absinthium L. and Tanacetum parthenium L.
Luísa Maria Silveira de Almeida, Lara Soares Aleixo de Carvalho, Matheus Coutinho Gazolla, Pedro Luiz Silva Pinto, Marcos Paulo Nascimento da Silva, Josué de Moraes, Ademar A. Da Silva Filho, Andrea Maxia   +7 more
wiley   +1 more source

Piplartine, a Bioactive Amide from Piper truncatum, Displays Potent Anthelmintic Activity Against the Zoonotic Nematode Angiostrongylus cantonensis

Chemistry
Parasitic nematodes, such as the zoonotic rat lungworm Angiostrongylus cantonensis, pose a significant global health burden, with current anthelmintics like albendazole showing limited efficacy.
Lucas Fukui-Silva, Sophia C. Spoladore, Bruna L. Lemes, Camila S. Amorim, Marina M. Gonçalves, João Henrique G. Lago, Josué de Moraes   +6 more
doaj   +1 more source

Dinâmica espacial e temporal das doenças tropicais negligenciadas no Arquipélago do Marajó, Amazônia-PA

Revista de Epidemiologia e Controle de Infecção, 2023
Justificativa e objetivo: a população autodenominada de marajoara encontra-se em vulnerabilidade devido às negligências de serviços básicos regidos na constituição, como saneamento básico, saúde e educação.
Enilde Santos de Aguiar, Alcione Pinheiro de Oliveira, Marcelo Coelho Simões, Altem Nascimento Pontes   +3 more
doaj   +1 more source

Inovação, propriedade intelectual e acesso a medicamentos e vacinas: o debate internacional na pandemia da Covid-19

Liinc em Revista, 2020
Este estudo analisa o debate internacional sobre vários aspectos do acesso a produtos de saúde, notadamente medicamentos e vacinas, no âmbito da Covid-19: estratégias de inovação (por exemplo, reposicionamento de fármacos), a discussão pública de alto ...
Claudia Chamas
doaj   +1 more source

Bioactive small molecules produced by the human gut microbiome modulate Vibrio cholerae sessile and planktonic lifestyles

Gut Microbes, 2021
Humans live in symbiosis with a diverse community of microorganisms, which has evolved to carry out many specific tasks that benefit the host, including protection against invading pathogens.
Heidi Pauer, Felipe Lopes Teixeira, Avery V. Robinson, Thiago E. Parente, Marília A. F. De Melo, Leandro A. Lobo, Regina M. C. P. Domingues, Emma Allen-Vercoe, Rosana B. R. Ferreira, Luis Caetano M. Antunes   +9 more
doaj   +1 more source

Doenças negligenciadas e bioética: diálogo de um velho problema com uma nova área do conhecimento

Revista Bioética
As doenças negligenciadas representam flagelo persistente no histórico das populações excluídas, sendo, portanto, objeto de interesse da bioética.
Bruno Leonardo Alves de Andrade, Dais Gonçalves Rocha   +1 more
doaj   +1 more source