Results 91 to 100 of about 1,447,809 (294)

Combined atypical primary hypoadrenocorticism and primary hypothyroidism in a dog [PDF]

, 2016
A dog with combined atypical primary hypoadrenocorticism and primary hypothyroidism is described. The dog presented with waxing and waning, vague complaints since more than a year and had been treated with several drugs without complete resolution of ...
Binst, Dominique, Daminet, Sylvie, Martlé, Valentine, Paepe, Dominique, Smets, Pascale, Vanmal, Britt   +5 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Feeding fresh food and providing water ad libitum is clinically proven to exceed calculated daily water requirements and impact urine relative supersaturation in dogs

Frontiers in Veterinary Science
A series of studies were conducted to evaluate a fresh food for its impact on total water consumption compared to a dry or canned pet food and urine relative supersaturation in healthy adult dogs.
Rae Sires, Ryan Yamka, Joe Wakshlag
doaj   +1 more source

Muscle co-contraction modulates damping and joint stability in a three-link bio mechanical limb

Frontiers in Neurorobotics, 2012
Computational models of neuromotor control require forward models of limb movement that can replicate the natural relationships between muscle activation and joint dynamics without the burdens of excessive anatomical detail. We present a model of a three-
Stewart eHeitmann, Stewart eHeitmann, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear, Norm eFerns, Norm eFerns   +7 more
doaj   +1 more source

Demand forecasting for companies with many branches, low sales numbers per product, and non-recurring orderings [PDF]

, 2006
We propose the new Top-Dog-Index to quantify the historic deviation of the supply data of many small branches for a commodity group from sales data. On the one hand, the common parametric assumptions on the customer demand distribution in the literature ...
Kurz, Sascha, Rambau, Joerg
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

What aspects of the pandemic had the greatest impact on adolescent mental health: duration of lockdown or subjective experience?

Child and Adolescent Psychiatry and Mental Health
Background The COVID-19 pandemic negatively impacted global mental health, with adolescents experiencing disproportionate effects. Limited research has explored the impact of different pandemic restrictions on adolescent mental health, and only a few ...
Hiroko Fujimoto, Anita Heywood, Kate Maston, Lyndsay Brown, Alexandra Bartholomew, Aliza Werner-Seidler, Helen Christensen, Philip J. Batterham   +7 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Mapping dynamic social networks in real life using participants' own smartphones

Heliyon, 2015
Interpersonal relationships are vital for our daily functioning and wellbeing. Social networks may form the primary means by which environmental influences determine individual traits.
Tjeerd W. Boonstra, Mark E. Larsen, Helen Christensen   +2 more
doaj   +1 more source

Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States

Canine Medicine and Genetics, 2020
Background The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, receives comparable medical care ...
Silvan R. Urfer, Matt Kaeberlein, Daniel E. L. Promislow, Kate E. Creevy   +3 more
doaj   +1 more source