Results 101 to 110 of about 1,365,954 (292)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Feeding fresh food and providing water ad libitum is clinically proven to exceed calculated daily water requirements and impact urine relative supersaturation in dogs

Frontiers in Veterinary Science
A series of studies were conducted to evaluate a fresh food for its impact on total water consumption compared to a dry or canned pet food and urine relative supersaturation in healthy adult dogs.
Rae Sires, Ryan Yamka, Joe Wakshlag
doaj   +1 more source

CAN PEOPLE DISTINGUISH PÂTÉ FROM DOG FOOD? [PDF]

Considering the similarity of its ingredients, canned dog food could be a suitable and inexpensive substitute for pâté or processed blended meat products such as Spam or liverwurst.
Bohannon, John, Goldstein, Robin, Herschkowitsch, Alexis   +2 more
core   +1 more source

A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17 [PDF]

, 2015
Closed breeding populations in the dog in conjunction with advances in gene mapping and sequencing techniques facilitate mapping of autosomal recessive diseases and identification of novel disease-causing variants, often using unorthodox experimental ...
A McKenna, András M. Komáromy, Cathryn Mellersh, D Gilliam, D Gould, D Hubmacher, Degui Zhi, FH Farias, G Lim, H Li, HG Parker, HM Kang, J Guo, J Guo, J Kuchtey, J Kuchtey, J Morales, JT Robinson, L Mosyak, Louise Pettitt, N Safra, N Siva, Oliver P. Forman, P Danecek, Peter Bedford, S Porter, S Purcell, SJ Ahonen   +27 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

What aspects of the pandemic had the greatest impact on adolescent mental health: duration of lockdown or subjective experience?

Child and Adolescent Psychiatry and Mental Health
Background The COVID-19 pandemic negatively impacted global mental health, with adolescents experiencing disproportionate effects. Limited research has explored the impact of different pandemic restrictions on adolescent mental health, and only a few ...
Hiroko Fujimoto, Anita Heywood, Kate Maston, Lyndsay Brown, Alexandra Bartholomew, Aliza Werner-Seidler, Helen Christensen, Philip J. Batterham   +7 more
doaj   +1 more source

The iBobbly Aboriginal and Torres Strait Islander app project: Study protocol for a randomised controlled trial

Trials, 2019
Background Suicide amongst Australian Aboriginal and Torres Strait Islander communities occurs at twice the rate of the general population and, with significant barriers to treatment, help-seeking prior to a suicide attempt is low.
Fiona Shand, Andrew Mackinnon, Kathleen O’Moore, Rebecca Ridani, Bill Reda, Mel Hoy, Todd Heard, Luke Duffy, Marian Shanahan, Lisa Jackson Pulver, Helen Christensen   +10 more
doaj   +1 more source

The Dog Whisperer [PDF]

, 2011
Zack Davis ’14 finds practice and teamwork is vital to his success as a dog trainer – and Linfield ...
Davis, Laura
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Muscle co-contraction modulates damping and joint stability in a three-link bio mechanical limb

Frontiers in Neurorobotics, 2012
Computational models of neuromotor control require forward models of limb movement that can replicate the natural relationships between muscle activation and joint dynamics without the burdens of excessive anatomical detail. We present a model of a three-
Stewart eHeitmann, Stewart eHeitmann, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear, Norm eFerns, Norm eFerns   +7 more
doaj   +1 more source