Results 61 to 70 of about 319,765 (294)

Tapping into truth: an exploratory cross-sectional analysis of psychomotor symptoms and typing behaviour in an adolescent observational cohort

NPP-Digital Psychiatry and Neuroscience
Typing behaviour derived from smartphone keystroke metadata is an emerging digital phenotype that may assist in diagnosing and monitoring depressive symptoms.
Taylor A. Braund, Debopriyo Bal, Helen Christensen, Philip J. Batterham, Bojana Vilus, Kate Maston, Mark E. Larsen, Aliza Werner-Seidler, Kit Huckvale, Alexis E. Whitton, Gabriel Tillman, Bridianne O’Dea   +11 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Feeding fresh food and providing water ad libitum is clinically proven to exceed calculated daily water requirements and impact urine relative supersaturation in dogs

Frontiers in Veterinary Science
A series of studies were conducted to evaluate a fresh food for its impact on total water consumption compared to a dry or canned pet food and urine relative supersaturation in healthy adult dogs.
Rae Sires, Ryan Yamka, Joe Wakshlag
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

What aspects of the pandemic had the greatest impact on adolescent mental health: duration of lockdown or subjective experience?

Child and Adolescent Psychiatry and Mental Health
Background The COVID-19 pandemic negatively impacted global mental health, with adolescents experiencing disproportionate effects. Limited research has explored the impact of different pandemic restrictions on adolescent mental health, and only a few ...
Hiroko Fujimoto, Anita Heywood, Kate Maston, Lyndsay Brown, Alexandra Bartholomew, Aliza Werner-Seidler, Helen Christensen, Philip J. Batterham   +7 more
doaj   +1 more source

The iBobbly Aboriginal and Torres Strait Islander app project: Study protocol for a randomised controlled trial

Trials, 2019
Background Suicide amongst Australian Aboriginal and Torres Strait Islander communities occurs at twice the rate of the general population and, with significant barriers to treatment, help-seeking prior to a suicide attempt is low.
Fiona Shand, Andrew Mackinnon, Kathleen O’Moore, Rebecca Ridani, Bill Reda, Mel Hoy, Todd Heard, Luke Duffy, Marian Shanahan, Lisa Jackson Pulver, Helen Christensen   +10 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Codesigned online cognitive bias modification of interpretations for anxiety and depression in children: study protocol of a randomised controlled trial

BMJ Open
Introduction Previous research has shown that cognitive bias modification of interpretations (CBM-I) may be a promising intervention for anxiety in youth; however, results are mixed.
Andrew Mackinnon, Elske Salemink, Gemma Sicouri, Emily Daniel, Abigail Allsop, Jennifer Hudson   +5 more
doaj   +1 more source

Muscle co-contraction modulates damping and joint stability in a three-link bio mechanical limb

Frontiers in Neurorobotics, 2012
Computational models of neuromotor control require forward models of limb movement that can replicate the natural relationships between muscle activation and joint dynamics without the burdens of excessive anatomical detail. We present a model of a three-
Stewart eHeitmann, Stewart eHeitmann, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear, Norm eFerns, Norm eFerns   +7 more
doaj   +1 more source