Results 61 to 70 of about 1,365,954 (292)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Comment on Hladky-Krage, B.; Hoffman, C.L. Expectations versus Reality of Designer Dog Ownership in the United States. Animals 2022, 12, 3247

Animals
Designer dogs—the result of intentionally crossbreeding purebred dogs, and specifically poodle mixes (a cross between a poodle and a second breed)—have rapidly grown in popularity in recent years [...]
Amanda J. Venturino, Katie M. Weaver, Cornelia Kraus, Jessica P. Hekman   +3 more
doaj   +1 more source

Exploring the lived experience of mental health and coping during unemployment

BMC Public Health, 2022
Background Unemployment is known to involve various psychosocial challenges that can negatively impact mental health. However, the intricacies of how individuals experience these challenges and strive to cope within the context of varied sociocultural ...
Andrew F. Arena, Marnie Harris, Sophia Mobbs, Alexandra Nicolopoulos, Samuel B. Harvey, Mark Deady   +5 more
doaj   +1 more source

Designing programs for eliminating canine rabies from islands: Bali, Indonesia as a case study [PDF]

, 2013
<p>Background: Canine rabies is one of the most important and feared zoonotic diseases in the world. In some regions rabies elimination is being successfully coordinated, whereas in others rabies is endemic and continues to spread to uninfected ...
AAG Putra, AAG Putra, AAG Putra, Anak Agung Gde Putra, Ayu P. M. Dewi, B Chomel, C Fraser, C Windiyaningsih, Charles E. Rupprecht, Corlevin Kalalo, CP Jewell, Daniel T. Haydon, Darryn L. Knobel, Dewa Made Ngurah Dharma, Elly F. Hiby, Eric Brum, Gusti Ngurah Bagus, H Si, Helen Scott–Orr, HL Beyer, I Ketut Gunata, I Putu Sumantra, I Wayan Mardiana, I Wayan Sukanadi, IKE Supartika, J Wallinga, Janice Girardi, JO Lloyd-Smith, Jonathan Dushoff, K Hampson, K Hampson, Katie Hampson, KR Margawani, Luuk Schoonman, M Song, MC Schneider, MC Schneider, Mike Shand, NC Grassly, NM Susilawathi, Pebi Purwo Suseno, PG Coleman, PJ Bacon, PM Kitala, Pudjiatmoko, , Sally Crafter, Sarah Cleaveland, SE Townsend, Sunny E. Townsend, Tenzin, Tenzin, WR Dowdle   +51 more
core   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mental health and mindfulness amongst Australian fire fighters

BMC Psychology, 2019
Background While extensive research has highlighted the positive mental health outcomes associated with mindfulness, little work has examined how mindfulness may protect the mental health of first responders exposed to trauma.
Isabelle Counson, Dominic Hosemans, Tara J. Lal, Brendan Mott, Samuel B. Harvey, Sadhbh Joyce   +5 more
doaj   +1 more source

Frequency estimation of disease-causing mutations in the Belgian population of some dog breeds, part 1 : shepherds [PDF]

, 2016
In light of improving breeding advice, the frequency was estimated for all the disease-causing mutations that were known at the start of the study and that are potentially relevant for a group of dog breeds, which are relatively popular or in which the ...
Beckers, Evy, Peelman, Luc, Ronsyn, L, Van Poucke, Mario   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Successful medical management of an epidural abscess in a dog [PDF]

, 2017
A seven-month-old entire male dobermann presented with acute onset neck pain and left thoracic limb lameness. The dog had a similar episode eight weeks before presentation that responded to meloxicam.
Durand, Alexane, Gutierrez-Quintana, Rodrigo, Jose-Lopez, Roberto, Romero-Fernancez, Nora   +3 more
core   +1 more source

Community perceptions of free-roaming dogs and management practices in villages at the periphery of a protected area in Bhutan [PDF]

, 2020
In Bhutan, free-roamingdogs pose health hazards to human, livestock, andwildlife. Understanding the perceptions and practices of local communitiesregarding free-roaming dogs is important to mitigate negative impacts. A community-based study was conducted
De Garine-Wichatitsky, Michel, Dorji, Tshering, Phimpraphai, Waraphon, Rinzin, Karma, Tenzin, Tenzin   +4 more
core   +1 more source