Results 41 to 50 of about 8,232 (233)

Factors regarding the dog owner’s household situation, antisocial behaviours, animal views and animal treatment in a population of dogs confiscated after biting humans and/ or other animals

PLoS ONE, 2023
To examine the dog ownership factors characteristic to a population of dogs confiscated after a human and/ or animal-directed biting incident, we compared bite risk assessment reports of 159 confiscated dogs in the time frame 2008, 2009, 2010 (tf1) and ...
Ineke R. van Herwijnen, Joanne A. M. van der Borg, Chantal M. Kapteijn, Saskia S. Arndt, Claudia M. Vinke   +4 more
doaj   +2 more sources

Spatial Analysis of Dog Ownership and Car Use in the UK

Findings, 2021
Walking the dog, and other dog-related practices, have been suggested to be particularly car-dependent. Secondary data analysis presented finds associations between the high energy use practices of car travel and dog ownership.
Ian Philips, Giulio Mattioli, Jillian Anable   +2 more
doaj   +1 more source

Expectations Versus Reality: Long-Term Research on the Dog–Owner Relationship

Animals, 2020
In the framework of the early prevention of problems in the owner–dog relationship, it is important to have a broad perspective on the development of this relationship over time, starting before people actually acquire a dog.
Esther M. C. Bouma, Lonneke M. Vink, Arie Dijkstra   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Association between dog ownership and type 2 diabetes in later life: the Helsinki birth cohort study

International Journal of Circumpolar Health, 2019
Dog ownership has been reported to have beneficial effects on physical activity and emotional well-being, both known to reduce the risk for type 2 diabetes (T2D).
Merja K. Laine, Niko S. Wasenius, Hannes Lohi, Mika Simonen, Katriina Tiira, Johan G. Eriksson, Minna K. Salonen   +6 more
doaj   +1 more source

Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children's study.

PLoS ONE, 2020
OBJECTIVES:No previous study has used repeated measures data to examine the associations of dog/cat ownership with wheezing and asthma prevalence among children.
Yu Taniguchi, Shin Yamazaki, Takehiro Michikawa, Shoji F Nakayama, Makiko Sekiyama, Hiroshi Nitta, Hidetoshi Mezawa, Mayako Saito-Abe, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Masayuki Shimono, Reiko Suga   +15 more
doaj   +1 more source

“In times of stress, it is good to be with them”: experience of dog owners from a rural district of Sri Lanka

BMC Public Health, 2022
Background The dog has been man’s best companion since ancient times. And, dog ownership is associated with improved physical activity and cardiovascular health.
Devarajan Rathish, Jayanthe Rajapakse, Kosala Weerakoon   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source