Results 51 to 60 of about 163,909 (281)

Development of the cat-owner relationship scale (CORS) [PDF]

, 2017
Characteristics of the human-animal bond can be influenced by both owner-related and pet-related factors, which likely differ between species. Three studies adapted the Monash Dog-Owner Relationship Scale (MDORS) to permit assessment of human-cat ...
American Veterinary Medical Association, Anderson, Animal Health Alliance, Anna Holloway, Bradshaw, Downey, Dwyer, Emerson, Herzog, Howell, Jaume Fatjó, Johnson, Jonathan Bowen, Lago, Miller, Paula Calvo, Pauleen C. Bennett, People’s Dispensary for Sick Animals, Staats, Templer, Tiffani J. Howell, Wilson, Wilson, Winefield, Zasloff, Zasloff   +25 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Association between dog ownership and type 2 diabetes in later life: the Helsinki birth cohort study

International Journal of Circumpolar Health, 2019
Dog ownership has been reported to have beneficial effects on physical activity and emotional well-being, both known to reduce the risk for type 2 diabetes (T2D).
Merja K. Laine, Niko S. Wasenius, Hannes Lohi, Mika Simonen, Katriina Tiira, Johan G. Eriksson, Minna K. Salonen   +6 more
doaj   +1 more source

Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children's study.

PLoS ONE, 2020
OBJECTIVES:No previous study has used repeated measures data to examine the associations of dog/cat ownership with wheezing and asthma prevalence among children.
Yu Taniguchi, Shin Yamazaki, Takehiro Michikawa, Shoji F Nakayama, Makiko Sekiyama, Hiroshi Nitta, Hidetoshi Mezawa, Mayako Saito-Abe, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Masayuki Shimono, Reiko Suga   +15 more
doaj   +1 more source

“In times of stress, it is good to be with them”: experience of dog owners from a rural district of Sri Lanka

BMC Public Health, 2022
Background The dog has been man’s best companion since ancient times. And, dog ownership is associated with improved physical activity and cardiovascular health.
Devarajan Rathish, Jayanthe Rajapakse, Kosala Weerakoon   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A cross-sectional exploratory analysis between pet ownership and sleep, exercise, health and neighborhood perceptions : The Whitehall II cohort study [PDF]

, 2018
A cross-sectional exploratory analysis between pet ownership and sleep, exercise, health and neighbourhood perceptions: The Whitehall II cohort study Gill Mein (corresponding author), Robert Grant.
A Bauman, A Singh-Manoux, AC Davidson, B Headley, BA Kingwell, BE Ainsworth, C Krause-Parello, C Westgarth, D Goldberg, D Jenkins, G Mein, Gill Mein, H Cutt, J McNicholas, JE Ware, K Reid, KM Allen, LS Radloff, M Basner, M Hyde, M Marmot, M Stafford, M Stafford, MF Folstein, MM Ohayon, N Seigel, R Parlsow, Robert Grant, S Knight   +28 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The influence of dog ownership on objective measures of free-living physical activity and sedentary behaviour in community-dwelling older adults: a longitudinal case-controlled study

BMC Public Health, 2017
Background There is some evidence to suggest that dog ownership may improve physical activity (PA) among older adults, but to date, studies examining this, have either depended on self-report or incomplete datasets due to the type of activity monitor ...
Philippa Margaret Dall, Sarah Lesley Helen Ellis, Brian Martin Ellis, P Margaret Grant, Alison Colyer, Nancy Renee Gee, Malcolm Howard Granat, Daniel Simon Mills   +7 more
doaj   +1 more source

Do residents’ perceptions of being well-placed and objective presence of local amenities match? A case study in West Central Scotland, UK [PDF]

, 2013
Background:<p></p> Recently there has been growing interest in how neighbourhood features, such as the provision of local facilities and amenities, influence residents’ health and well-being.
A Crompton, A Ellaway, A Ellaway, A Ellaway, A Ellaway, A Gatrell, A Kearns, A Okabe, Ade Kearns, AG Scotland, Anne Ellaway, AP McGinn, D Altman, D Canter, D Fone, D Ogilvie, Department of Health, DJ Walmsley, E Coombes, E Leslie, EK Sadalla, F Li, G McCormack, G McCormack, J Pearce, J Tilt, K Ball, K Ball, K Donaldson, K Gebel, K Gebel, K Kirtland, K Smoyer-Tomic, L Lin, L Macdonald, L McNeill, L Moore, L Wood, Laura Macdonald, LK Williams, MA Jones, N Humpel, Office of Population Censuses and Surveys, P Apparicio, P Seaman, PM Hurvitz, R Briggs, R Cohen, R Harrison, R Hiscock, R Hiscock, S Lotfi, S Macintyre, S Macintyre, S Macintyre, S Macintyre, S Macintyre, S Macintyre, S Macintyre, TL Hawthorne, W Poortinga   +60 more
core   +1 more source