Results 101 to 110 of about 1,551,991 (408)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Acute febrile illness is associated with Rickettsia spp infection in dogs [PDF]

, 2015
BACKGROUND: Rickettsia conorii is transmitted by Rhipicephalus sanguineus ticks and causes Mediterranean Spotted Fever (MSF) in humans. Although dogs are considered the natural host of the vector, the clinical and epidemiological significance of R ...
A Cascio, A Estrada-Pena, A Mannelli, A Mura, A Ortuno, A Rojas, A Torina, A Torina, A Torina, A Znazen, Alessandra Caprì, AM Gasser, BA Stillman, C Colomba, C Riera, C Rovery, CP Ober, D Otranto, D Otranto, D Otranto, E Beeler, E Sanger, EB Breitschwerdt, F Segura-Porta, FJ Marquez, G Baneth, G Baneth, G Baneth, G Vitale, GB Andrade, GM Giammanco, GM Giammanco, H Inokuma, J Fuente de la, JC Garcia-Garcia, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, L Solano-Gallego, Laia Solano-Gallego, M Bernabeu-Wittel, M Rene-Martellet, M Sarih, Marco Caldin, Maria Grazia Pennisi, ME Eremeeva, ME Mylonakis, Michele Trotta, ML Levin, ML Levin, N Alexandre, N Cardenosa, NY Salem, P Brouqui, P Brouqui, P Parola, P Parola, PJ Kelly, S Delgado, S Harrus, S Harrus, S Santibanez, SE Little, T Beninati, T Furlanello, Tommaso Furlanello, WL Nicholson   +69 more
core   +3 more sources

A modified Sydney system for the diagnosis of chronic gastritis in dogs

Acta Veterinaria Scandinavica, 2020
Background The Sydney system for assessing inflammatory lesions in the gastric mucosa is based on endoscopic and histological examinations. This study aimed to apply the Sydney system to diagnose gastritis in dogs.
Jolanta Spużak, Marcin Jankowski, Krzysztof Kubiak, Kamila Glińska-Suchocka, Rafał Ciaputa   +4 more
doaj   +1 more source

Detecting acute kidney injury in horses by measuring the concentration of symmetric dimethylarginine in serum

Acta Veterinaria Scandinavica, 2021
Background Acute kidney injury (AKI) in horses may develop as a complication of a primary disease or following the administration of nephrotoxic drugs, and may pose a diagnostic challenge.
Natalia Siwinska, Agnieszka Zak, Urszula Paslawska   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Painted Ferocity: The Social Behaviors of African Wild Dogs, Threats to Survival, and Resulting Conservation Initiatives [PDF]

, 2018
African Wild Dogs (Lycaon pictus) are an endangered species of canid from Sub-Saharan Africa. They are very social communal hunters, and are capable of chasing down prey for long stretches of time. Wild dogs benefit a savannah ecosystem by regulating the
Valdes, Alexis
core   +1 more source

Eddington-Limited Accretion in z~2 WISE-selected Hot, Dust-Obscured Galaxies

, 2017
Hot, Dust-Obscured Galaxies, or "Hot DOGs", are a rare, dusty, hyperluminous galaxy population discovered by the WISE mission. Predominantly at redshifts 2-3, they include the most luminous known galaxies in the universe.
Aldering, Greg, Assef, Roberto J., Blain, Andrew, Boone, Kyle, Denney, Kelly D., Díaz-Santos, Tanio, Eisenhardt, Peter R. M., Fagrelius, Parker, Hayden, Brian T., Jun, Hyunsung D., Perlmutter, Saul, Stern, Daniel, Tsai, Chao-Wei, Wright, Edward L., Wu, Jingwen   +14 more
core   +1 more source

Preliminary Investigation of Food Guarding Behavior in Shelter Dogs in the United States [PDF]

, 2012
Even though food guarding is an adaptive trait for dogs, they are often euthanized when they exhibit this behavior while at an animal shelter. This research demonstrates some dogs that guard their food can be adopted and guarding is seldom seen in the ...
Emily Weiss, Heather Mohan-Gibbons, Margaret Slater   +2 more
core   +2 more sources

Acquiring a Pet Dog: A Review of Factors Affecting the Decision-Making of Prospective Dog Owners

Animals, 2019
Given the prevalence of pet dogs in households throughout the world, decisions regarding dog acquisition affect many people each year. Across the stages of dog acquisition there is potential for practices that may promote or compromise canine welfare ...
Katrina E. Holland
doaj   +1 more source

Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats [PDF]

, 2021
Tarcísio Guerra Guimarães, Karla Menezes Cardoso, Pedro Tralhão, Carlos Miguel Marto, Nuno Alexandre, Maria Filomena Botelho, Mafalda Laranjo   +6 more
openalex   +1 more source