Results 101 to 110 of about 1,160,033 (345)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

The impact of living with assistance dog placements on quality of life in children and adults with autism spectrum disorder or a physical disability: A longitudinal service evaluation

Human-Animal Interactions
Assistance dogs are highly trained animals to support individuals with disabilities and medical conditions. Evidence suggests the support provided by an assistance dog can extend beyond physical assistance to therapeutic and communicative domains ...
Emily Shoesmith, Selina Gibsone, Ed Bracher, Iris Smolkovič, Kelly Jennings, Laura Viles, Kate Easton, Elena Ratschen   +7 more
doaj   +1 more source

Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review

Frontiers in Veterinary Science, 2020
Osteoarthritis is a common clinical and pathological end-point from a range of joint disorders, that ultimately lead to structural and functional decline of the joint with associated lameness and pain.
Katharine L. Anderson, Katharine L. Anderson, Helen Zulch, Dan G. O'Neill, Richard L. Meeson, Lisa M. Collins   +5 more
doaj   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Fleece-Lined Whelping Pools Associated with Reduced Incidence of Canine Hip Dysplasia in a Guide Dog Program

Animals
Using genetic selection, Guide Dogs for the Blind (GDB) has reduced the incidence rate of canine hip dysplasia (CHD). However, given that CHD is polygenic and multifactorial, environmental factors may impact the expression of this developmental condition.
Lynna C. Feng, Alexandra Philippine, Elizabeth Ball-Conley, Sarah-Elizabeth Byosiere   +3 more
doaj   +1 more source

The detection of capsaicin and dihydrocapsaicin in horse serum following long-term local administration

BMC Veterinary Research, 2018
Background Capsaicin and dihydrocapsaicin are alkaloids with analgesic effects in humans and animals. When used locally, both of them minimalise pain sensation by defunctionalising nerve endings.
A. Zak, N. Siwinska, M. Slowikowska, H. Borowicz, P. Szpot, M. Zawadzki, A. Niedzwiedz   +6 more
doaj   +1 more source

Endoscopic laser-ablation for the treatment of orthotopic and ectopic ureteroceles in dogs: 13 cases (2008-2017). [PDF]

, 2019
BACKGROUND: Ureteroceles are a rare condition in dogs in which conventional treatments can result in substantial morbidity. Cystoscopic and fluoroscopic-guided laser ablation (CLA) of ureteroceles can successfully relieve obstruction.
Ather MH, Ettinger S, Hoffman S, Martin RA, McLoughlin MA, Ross LA, Scott RC, Stowater JL, Tobias K, Van Batavia JP   +9 more
core   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland

BMC Veterinary Research, 2017
Background There are no available studies describing the possible resistance of strongyles to ivermectin in horses in Poland. One hundred seventy three horses from nine stud farms from South-Western Poland were studied.
A. Zak, N. Siwinska, M. Slowikowska, H. Borowicz, K. Kubiak, J. Hildebrand, M. Popiolek, A. Niedzwiedz   +7 more
doaj   +1 more source

Why do dogs (Canis familiaris) select the empty container in an observational learning task? [PDF]

, 2011
Many argue that dogs show unique susceptibility to human communicative signals that make them suitable for being engaged in complex co-operation with humans.
A Cleveland, A Dijksterhuis, A Senju, A Senju, AN Meltzoff, B Hare, B Hare, C Schwier, C Tennie, C Teuscher, D Buttelmann, D Buttelmann, F Range, F Range, F Range, F Warneken, G Csibra, G Gergely, G Gergely, G Gergely, György Gergely, H Bekkering, H Moll, H Moll, HC Miller, I Király, J Bräuer, J Kaminski, J Riedel, J Topál, J Topál, J Topál, J Topál, J Topál, J Topál, JMD Yoon, József Topál, Krisztina Kupán, M Carpenter, M Carpenter, M Gácsi, M Gácsi, M Nielsen, M Tomasello, M Tomasello, M Tomasello, MJ Rochat, N Wood, P Pongrácz, P Prato-Previde, P Ricciardelli, PJ Reid, T Grossmann, V Horner, V Szetei, Zs Virányi, Á Erdőhegyi, Á Miklósi, Ádám Miklósi   +58 more
core   +1 more source