Results 111 to 120 of about 538,376 (309)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Maximizing the Quality of Non‐Invasive Samples for Conservation Genetics Using Targeted Next‐Generation Sequencing: A Comparison of Fecal DNA Preservation Methodologies

Ecology and Evolution
Non‐invasive DNA sampling from feces can provide powerful tools for wildlife research, management, and conservation. However, obtaining high quality and quantity fecal DNA is notoriously problematic, being affected by many different variables.
Alexis L. Levengood, Katrin Hohwieler, Daniel Powell, Romane H. Cristescu   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Dog Theft: A Case for Tougher Sentencing Legislation

Animals, 2018
Dogs, and other companion animals, are currently classed as “property” in theft sentencing legislation for England and Wales. This means that offenders who steal dogs are given similar sentences to those that steal inanimate objects. This review presents
Lauren K. Harris
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Exploring the potential role of built environments in wildlife conservation during wildfires

Conservation Science and Practice
As the frequency and severity of wildfires continue to rise, fire refugia could play a critical role in reducing impacts on affected wildlife species.
Katrin Hohwieler, Carmen Piza Roca, Elizabeth Brunton, Michelle Ward, Romane H. Cristescu   +4 more
doaj   +1 more source

Supporting Families to ‘Make the Most’ of the Relationship Between Their Companion Dogs and Their Children with Autism Spectrum Condition: A Qualitative Exploration of the ‘Family Dog Service’

Behavioral Sciences
Evidence suggests that assistance and therapy dogs can positively impact the mental and physical health of children with autism spectrum condition (ASC) and their families. However, these services are often costly and inaccessible.
Emily Shoesmith, Heidi Stevens, Selina Gibsone, Cari Miles, Hannah Beal, Kelly Jennings, Elena Ratschen   +6 more
doaj   +1 more source

Factors influencing the development and carbohydrate metabolism of Echinococcus granulosus in dogs [PDF]

, 1998
Echinococcus granulosus adult worms, 35 days postinfection, were measured for dispersion in the intestines of 10 dogs, a range of morphological characters, and the excreted end products of carbohydrate catabolism following 4 hr incubation in vitro.
Bennet-Jenkins, E.M., Behm, C.A., Thompson, R.C.A., Constantine, C., Lymbery, A.J., Jenkins, D.J.   +5 more
core  

Evaluation of PCR as a diagnostic mass-screening tool to detect Leishmania (Viannia) spp. in domestic dogs (Canis familiaris)

, 2003
Several studies have suggested that the PCR could be used in epidemiological mass-screening surveys to detect Leishmania (Piannia) spp. infection in human and animal hosts.
Reithinger, Richard, Courtenay, Orin, Espinoza, Juan Canales, J. C. Espinoza, R. Reithinger, C. R. Davies, O. Courtenay, Davies, Clive R   +7 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source