Results 101 to 110 of about 538,376 (309)

The detection of capsaicin and dihydrocapsaicin in horse serum following long-term local administration

BMC Veterinary Research, 2018
Background Capsaicin and dihydrocapsaicin are alkaloids with analgesic effects in humans and animals. When used locally, both of them minimalise pain sensation by defunctionalising nerve endings.
A. Zak, N. Siwinska, M. Slowikowska, H. Borowicz, P. Szpot, M. Zawadzki, A. Niedzwiedz   +6 more
doaj   +1 more source

Heterogeneities in leishmania infantum infection : using skin parasite burdens to identify highly infectious dogs [PDF]

, 2013
Background: The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management.
Quinnell, Rupert J., Leo Calvo-Bado (507757), Orin Courtenay (103643), Lourdes M. Garcez (103639), Rupert J Quinnell, Calvo-Bado, L, Rupert J. Quinnell, Quinnell Rupert J., Courtenay, Orin, Connor Carson, Garcez Lourdes M., Calvo-Bado, Leo A., Leo Calvo-Bado, Garcez, LM, Connor Carson (103631), Courtenay, O, Calvo-Bado Leo, Rupert J. Quinnell (103626), Quinnell, RJ, Garcez, Lourdes M., Carson, Connor, Lourdes M Garcez, Orin Courtenay, Courtenay Orin, Carson Connor, Carson, C, Lourdes M. Garcez   +26 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Predicting guide dog career success using machine learning and large language models

Scientific Reports
Guide dogs play essential roles in supporting independence and well-being of visually impaired people. High attrition rates underscore the need for more effective early prediction of dog suitability for a guide dog career.
Adir Solomon, Elena Shamis, Hadas Racah, Amihai Toren, Carmel Weiss, Orna Braun, Anna Zamansky   +6 more
doaj   +1 more source

Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland

BMC Veterinary Research, 2017
Background There are no available studies describing the possible resistance of strongyles to ivermectin in horses in Poland. One hundred seventy three horses from nine stud farms from South-Western Poland were studied.
A. Zak, N. Siwinska, M. Slowikowska, H. Borowicz, K. Kubiak, J. Hildebrand, M. Popiolek, A. Niedzwiedz   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Acute phase protein levels in dogs with mast cell tumours and sarcomas [PDF]

, 2012
<p><b>Context:</b> The acute phase protein response is part of a non-specific and complex host response to inflammation. It occurs shortly after tissue injury and may be induced by a range of different causes, including infectious ...
PRATSCHKE, Jonathan, Parkin T., Chase D., Pratschke, J., G. McLauchlan, Pratschke, K., Eckersall P. D., Chase, D., Parkin, T., K. Pratschke, Pratschke J., P. D. Eckersall, Pratschke K., McLauchlan G., D. Chase, Eckersall, P. D., McLauchlan, G., T. Parkin, Eckersall, P., J. Pratschke   +19 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Biomarkers of injury to neural tissue in veterinary medicine

Journal of Veterinary Research, 2016
There are numerous biomarkers of central and peripheral nervous system damage described in human and veterinary medicine. Many of these are already used as tools in the diagnosis of human neurological disorders, and many are investigated in regard to ...
Płonek Marta, Wrzosek Marcin, Nicpoń Józef   +2 more
doaj   +1 more source

A national study of gastrointestinal parasites infecting dogs and cats in Australia [PDF]

, 2008
Despite the popularity of companion animal ownership in Australia, recent and comprehensive information with regard to the prevalence, epidemiology and public health significance associated with gastrointestinal parasites of pet dogs and cats in ...
Holyoake, Carlysle Sian
core