Results 131 to 140 of about 470,246 (313)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Cryptosporidium spp. in domestic dogs: the "dog" genotype [PDF]

open access: yes, 2000
Genetic and phylogenetic characterization of Cryptosporidium isolates at two loci (18S rRNA gene and heat shock gene) from both Australian and United States dogs demonstrated that dog-derived Cryptosporidium isolates had a distinct genotype which is ...
Monis, P.   +9 more
core   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

The use of dogs in California public schools: current use, support for, potential concerns and educator familiarity with potential benefits [PDF]

open access: yes, 2002
Plan BThe purpose of this study was to determine the current use of dogs in California public schools, to determine the familiarity of various educators, in particular school psychologists and school counselors with pet facilitated therapy, to determine ...
Ryan, Holly McLean
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

The management of the stud dog and brood bitch [PDF]

open access: yes, 1901
É separata de: Our ...
Marples, Theo
core  

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Bad Dogs Exhibition [PDF]

open access: yes, 2008
The fashionable crowd are a fickle bunch, with many unspoken dress rules sorting the fashionably elite to the fashionably obsolete. The exhibition Bad Dogs, is all about breaking these codes of conduct in the fashion world and poking fun at the oh so ...
Rissanen, TI
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Target-controlled infusion of propofol in dogs - Evaluation of four targets for induction of anaesthesia [PDF]

open access: yes, 2005
Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2.5 μg/ml, 3.0 μg/m., 3.5 μg/ml or 4.0 μg/ml of propofol in blood.
Musk, G.C.
core   +1 more source

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