Results 151 to 160 of about 1,551,991 (408)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Domestic dog ownership in Iran is a risk factor for human infection with Leishmania infantum. [PDF]

, 2002
One explanation proposed for the widespread failure to control zoonotic visceral leishmaniasis by culling infected domestic dogs is that wild canids or humans play significant roles in transmission.
Davies, Clive R, Edrissian, Gholan H, Gavgani, A Samad Mazloumi, Mohebali, Mehdi, Mohite, Hassan   +4 more
core   +1 more source

Supporting Families to ‘Make the Most’ of the Relationship Between Their Companion Dogs and Their Children with Autism Spectrum Condition: A Qualitative Exploration of the ‘Family Dog Service’

Behavioral Sciences
Evidence suggests that assistance and therapy dogs can positively impact the mental and physical health of children with autism spectrum condition (ASC) and their families. However, these services are often costly and inaccessible.
Emily Shoesmith, Heidi Stevens, Selina Gibsone, Cari Miles, Hannah Beal, Kelly Jennings, Elena Ratschen   +6 more
doaj   +1 more source

Canine Olfactory Thresholds to Amyl Acetate in a Biomedical Detection Scenario

Frontiers in Veterinary Science, 2019
Dogs' abilities to respond to concentrations of odorant molecules are generally deemed superior to electronic sensors. This sensitivity has been used traditionally in many areas; but is a more recent innovation within the medical field.
Astrid R. Concha, Astrid R. Concha, Claire M. Guest, Rob Harris, Thomas W. Pike, Alexandre Feugier, Helen Zulch, Helen Zulch, Daniel S. Mills   +8 more
doaj   +1 more source

Molecular Survey and Genetic Characteristics of Vector-Borne Pathogens in Domestic Dogs from Four Regions of China [PDF]

, 2023
Fangyuan Yin, Chuanjiang Guo, Dong Li, Zhuojia Tian, Facai Li   +4 more
openalex   +1 more source

Epidemiology of Cranial Cruciate Ligament Disease Diagnosis in Dogs Attending Primary-Care Veterinary Practices in England.

Veterinary surgery, 2015
OBJECTIVE To estimate the prevalence and risk factors for a diagnosis of cranial cruciate ligament (CCL) disease in dogs and to describe the management of such cases attending primary-care veterinary practices.
F. Taylor‐Brown, R. Meeson, D. Brodbelt, D. Church, P. McGreevy, P. Thomson, D. O'Neill   +6 more
semanticscholar   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

The Spectral Energy Distribution and Infrared Luminosities of z ≈ 2 Dust-obscured Galaxies from Herschel and Spitzer [PDF]

, 2012
Dust-obscured galaxies (DOGs) are a subset of high-redshift (z ≈ 2) optically-faint ultra-luminous infrared galaxies (ULIRGs, e.g., L_(IR) > 10^(12) L_☉). We present new far-infrared photometry, at 250, 350, and 500 μm (observed-frame), from the Herschel
Alberts, Stacey, Armus, Lee, Bussmann, R. S., Desai, Vandana, Dey, Arjun, Jannuzi, B. T., Melbourne, J., Pope, Alexandra, Soifer, B. T.   +8 more
core   +1 more source

Lung lobe torsion in adult and juvenile pugs [PDF]

, 2018
This cases series of 13 pugs with lung lobe torsion (LLT) is the largest case series of pugs in the literature and the first to compare dogs presenting before and after 12 months of age.
Adamantos, S, Holmes, A C, Humm, K R, Tivers, M S   +3 more
core   +2 more sources

Age Is Just a Number: No Impacts of Scat Ageing on Single Nucleotide Polymorphism Genotyping Using a Target Capture Approach

Ecology and Evolution
Recent advances in DNA sequencing and genotyping technologies are rapidly building our capacity to address ecological, evolutionary, and conservation questions for wildlife. However, wildlife genetic research increasingly relies on samples containing low
Alexis L. Levengood, Katrin Hohwieler, Daniel Powell, Romane H. Cristescu   +3 more
doaj   +1 more source