Results 61 to 70 of about 469,015 (313)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dogs as sources and sentinels of parasites in humans and wildlife, northern Canada

, 2008
A minimum of 11 genera of parasites, including 7 known or suspected to cause zoonoses, were detected in dogs in 2 northern Canadian communities. Dogs in remote settlements receive minimal veterinary care and may serve as sources and sentinels for ...
Brett T. Elkin, Douglas P. Whiteside, Thompson, R.C.A., Salb, Amanda L., Barkema, H.W., Black, S.R., Whiteside, D.P., R.C. Andrew Thompson, Kutz, S.J., Amanda L. Salb, Sandra R. Black, J.P. Dubey, Susan J. Kutz, Elkin, B.T., Herman W. Barkema, Dubey, J.P.   +15 more
core   +1 more source

New Strategies of Canine Post-Adoption Support: Methods for a Prospective Longitudinal Cohort Study

Animals
In 2018, Dogs Trust (UK) launched the Post Adoption Support project, the largest known prospective cohort study investigating behavioural and health problems post-rehoming of dogs.
Emma L. Buckland, Kassandra Giragosian, Eleanor J. Jordan, Rosa E. P. Da Costa, Joshua L. Woodward, Rachel A. Casey   +5 more
doaj   +1 more source

Two-dimensional echocardiographic measurements of the right coronary artery in healthy horses – a pilot study

BMC Veterinary Research, 2019
Background Precise understanding of the dimensions of the vascular lumina is essential for accurate interpretation of cardiac vessels imaging. To the authors’ best knowledge, this is the first study focusing on the ultrasound measurement of the right ...
Natalia Siwinska, Marcin Michalek, Agnieszka Zak, Malwina Slowikowska, Agnieszka Noszczyk-Nowak, Artur Niedzwiedz, Urszula Paslawska   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

UK Dog Owners’ Pre-Acquisition Information- and Advice-Seeking: A Mixed Methods Study

Animals
Dogs are the most common pet animal species in the UK. Little is known about information and advice gathering within the process of dog acquisition, nor what pre-acquisition research encompasses.
Rebecca Mead, Katrina E. Holland, Rachel A. Casey, Melissa M. Upjohn, Robert M. Christley   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effects of topical application of fipronil spot-on on dogs against the Chagas disease vector Triatoma infestans.

, 2009
We assessed the insecticidal effects of fipronil spot-on applied to experimental dogs on the blood-feeding success and other vital parameters of the Trypanosoma cruzi vector Triatoma infestans.
Reithinger, Richard, Gürtler, Ricardo E, Kitron, Uriel, Stariolo, Raúl, Ceballos, Leonardo A   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Chagas disease control: deltamethrin-treated collars reduce Triatoma infestans feeding success on dogs.

, 2005
Dogs are domestic reservoir hosts of Trypanosoma cruzi, the aetiological agent of Chagas disease. Using an experimental set-up mimicking rural mud-and-thatch houses, we evaluated the effect of deltamethrin-treated dog collars on the feeding success and ...
Reithinger, Richard, Ceballos, Leonardo, Gürtler, Ricardo E, Stariolo, Raúl, Davies, Clive R   +4 more
core   +1 more source