Results 71 to 80 of about 469,015 (313)

Heterogeneities in leishmania infantum infection : using skin parasite burdens to identify highly infectious dogs [PDF]

, 2013
Background: The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management.
Quinnell, Rupert J., Leo Calvo-Bado (507757), Orin Courtenay (103643), Lourdes M. Garcez (103639), Rupert J Quinnell, Calvo-Bado, L, Rupert J. Quinnell, Quinnell Rupert J., Courtenay, Orin, Connor Carson, Garcez Lourdes M., Calvo-Bado, Leo A., Leo Calvo-Bado, Garcez, LM, Connor Carson (103631), Courtenay, O, Calvo-Bado Leo, Rupert J. Quinnell (103626), Quinnell, RJ, Garcez, Lourdes M., Carson, Connor, Lourdes M Garcez, Orin Courtenay, Courtenay Orin, Carson Connor, Carson, C, Lourdes M. Garcez   +26 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A national study of gastrointestinal parasites infecting dogs and cats in Australia [PDF]

, 2008
Despite the popularity of companion animal ownership in Australia, recent and comprehensive information with regard to the prevalence, epidemiology and public health significance associated with gastrointestinal parasites of pet dogs and cats in ...
Holyoake, Carlysle Sian
core  

Holidaying with the family pet: No dogs allowed! [PDF]

, 2009
This paper assesses the extent to which dog owners located in Brisbane, Australia, wish to holiday with their pets, and whether there is a gap between this desire and reality.
Cohen, SA, Cohen, Scott, Carr, Neil, Carr, N   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A modified Sydney system for the diagnosis of chronic gastritis in dogs

Acta Veterinaria Scandinavica, 2020
Background The Sydney system for assessing inflammatory lesions in the gastric mucosa is based on endoscopic and histological examinations. This study aimed to apply the Sydney system to diagnose gastritis in dogs.
Jolanta Spużak, Marcin Jankowski, Krzysztof Kubiak, Kamila Glińska-Suchocka, Rafał Ciaputa   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Acquiring a Pet Dog: A Review of Factors Affecting the Decision-Making of Prospective Dog Owners

Animals, 2019
Given the prevalence of pet dogs in households throughout the world, decisions regarding dog acquisition affect many people each year. Across the stages of dog acquisition there is potential for practices that may promote or compromise canine welfare ...
Katrina E. Holland
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Wolves do not join the dance: Sophisticated aggression control by adjusting to human social signals in dogs

, 2013
In this study we aimed to investigate novel aspects of dogs' comprehension of human social behaviours by revealing potential differences in the responses of wolves and dogs when they interact with a human in socially ambiguous situations. In Experiment 1,
Gácsi, Márta, Miklósi, Ádám, Topál, József, Vas, Judit   +3 more
core   +1 more source