Results 91 to 100 of about 17,845 (225)

The role of dolutegravir in the management of HIV infections

, 2015
Misty M Miller,1 Michelle D Liedtke,1 Staci M Lockhart,2 R Chris Rathbun1 1Department of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA; 2AbbVie Inc., Oklahoma City, OK, USA Abstract ...
Miller MM, Rathbun RC, Liedtke MD, Lockhart SM   +3 more
core  

Prevalence of low‐level viremia and its association with virological failure among adolescents living with HIV in Eastern Cape, South Africa

HIV Medicine, Volume 27, Issue 6, Page 1018-1030, June 2026.
Abstract Objectives Low‐level viremia (LLV) has been associated with an increased risk of virological failure among adults on antiretroviral therapy (ART). However, evidence on the clinical implications of LLV among adolescents living with HIV remains limited.
Zea Leon, Olanrewaju Edun, Siyanai Zhou, Janke Tolmay, Lucie Cluver, Gayle Sherman, Ahmad H. Mazanderani, Elona Toska   +7 more
wiley   +1 more source

Switch to bictegravir/emtricitabine/tenofovir alafenamide from dolutegravir-based therapy

AIDS (London)
Objective: To evaluate the efficacy and safety of 96 weeks of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) treatment in participants switching from dolutegravir (DTG)-based therapy.
C. Orkin, A. Antinori, Jürgen K. Rockstroh, Santiago Moreno-Guillén, C. Martorell, J. Molina, Adriano Lazzarin, F. Maggiolo, Y. Yazdanpanah, Kristen N. Andreatta, Hailin Huang, J. Hindman, Hal Martin, A. Pozniak   +13 more
semanticscholar   +1 more source

Prevalence of Sleep Apnea and Sleepiness in Adults With and Without HIV in Mwanza, Tanzania: Baseline Results From an Ongoing Cohort Study

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
ABSTRACT We conducted a cross‐sectional analysis of the baseline survey of participants aged > 30 years enrolled in the Mwanza HIV&CVD Cohort in Tanzania. Our primary objective was to examine the association between HIV status and sleep apnea (SA).
Godfrey A. Kisigo, Benson Issarow, Salama Fadhil, Grace Ruselu, Ponsiano Fabian, Ayubu Garbindi, Robert N. Peck, Kathy Baisley, Saidi Kapiga, Ana C. Krieger   +9 more
wiley   +1 more source

Dolutegravir induces FOLR1 expression during brain organoid development

Frontiers in Molecular Neuroscience
During the first month of pregnancy, the brain and spinal cord are formed through a process called neurulation. However, this process can be altered by low serum levels of folic acid, environmental factors, or genetic predispositions.
Carlo Donato Caiaffa, Gabriel L Tukeman, Christian Z Delgado, Yogeshwari S. Ambekar, T. Mekonnen, Manmohan Singh, Victoria Rodriguez, Emily Ricco, D. Kraushaar, S. Aglyamov, G. Scarcelli, K. Larin, Richard H. Finnell, Robert M. Cabrera   +13 more
semanticscholar   +1 more source

PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1235-1248, May 2026.
Model‐informed drug development is increasingly integrated across the drug development continuum, enabling more efficient, cost‐effective, and targeted trials while reducing reliance on animal studies. Achieving pharmacoequity requires not only equitable access to medicines but also to the data and knowledge that inform drug development and regulatory ...
Shakir Atoyebi, Prajith Venkatasubramanian, Abdulafeez Akinloye, Oluwasegun Eniayewu, Brookie M. Best, Laura Else, Adeniyi Olagunju   +6 more
wiley   +1 more source

HIV viral suppression in children and adolescents 2 years after transition to dolutegravir: a multicentre cohort study

AIDS (London)
Background: Treatment failure is common among children and adolescents with HIV. Antiretroviral therapy (ART) containing dolutegravir has recently been rolled out across Africa, though long-term real-world data in paediatric populations are lacking. Here,
Akash Devendra, Maurus Kohler, Motlatsi Letsika, Hape Khooa, Lipontso Motaboli, Malebanye Lerotholi, Nadine Tschumi, N. Labhardt, J. Brown   +8 more
semanticscholar   +1 more source

Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible.

, 2018
We describe a case of virological failure during initial treatment with tenofovir disoproxil fumarate/emtricitabine/dolutegravir twice daily, with concomitant rifampin treatment of staphylococcal infection, selection of R263K + E157Q, and low plasma ...
Chueca, N, Pena, M J, D'Avolio, A, Garcia, F, Zarzalejos, J M   +4 more
core   +1 more source

The dolutegravir/valproic acid drug-drug interaction is primarily based on protein displacement

, 2021
Objectives: The dolutegravir/valproic acid drug-drug interaction (DDI) is suggested to be caused by protein displacement. Here, we assess the underlying mechanism.
De Mendonca Melo, M., Prins, H. A.B., Bax, H., Bax, H.; id_orcid, Velthoven-Graafland, K., De Vries-Sluijs, T. E.M.S., Rijnders, B. J.A.; id_orcid, Burger, D. M., Colbers, A., Van Nood, E., Rijnders, B. J.A., Nouwen, J., Rokx, C., Rokx, C.; id_orcid, Bollen, P. D.J., Verbon, A.   +15 more
core   +1 more source

Impact of switching to a dolutegravir‐based regimen on body weight changes: insights from West African adult HIV cohorts

Journal of the International AIDS Society
Adverse metabolic effects related to dolutegravir (DTG) are increasingly reported as countries are adopting DTG‐based regimens as first‐line antiretroviral therapy (ART), but there is limited data from sub‐Saharan Africa.
T. Tiendrebeogo, Karen Malateste, Armel G Poda, A. Minga, C. D. Lahiri, Oliver Ezechi, D. Ekouevi, I. Ofotokun, Antoine Jaquet   +8 more
semanticscholar   +1 more source