Results 71 to 80 of about 17,845 (225)

HIV drug resistance and treatment success in the Republic of Congo: Implications for optimized treatment

HIV Medicine, EarlyView.
Abstract Objectives Increasing rates of HIV‐1 drug resistance (HIVDR) threaten the effectiveness of antiretroviral therapy (ART) programmes in sub‐Saharan Africa, particularly among children, adolescents and young adults, who face limited treatment options.
Dominic Rauschning, Arcy Marcelin Elenga Ike, Johanna Holterhoff, Amira Stockinger, Darrel Ornelle Elion Assiana, Claujens Chastel Mfoutou Mapanguy, Freisnel Hermeland Mouzinga, Carola Horn, Isabelle Suarez, Ferdinand Heyn, Diane Alexia Fila, Hubert Banguissa, Fabien Roch Niama, Donatien Moukassa, Eva Heger, Francine Ntoumi, Clara Lehmann   +16 more
wiley   +1 more source

Standard-dose versus double-dose dolutegravir in HIV-associated tuberculosis in South Africa (RADIANT-TB): a phase 2, non-comparative, randomised controlled trial

The Lancet HIV, 2023
Summary Background The drug–drug interaction between rifampicin and dolutegravir can be overcome by supplemental dolutegravir dosing, which is difficult to implement in high-burden settings.
Rulan Griesel, Ying Zhao, Bryony Simmons, Zaayid Omar, L. Wiesner, C. Keene, Andrew M. Hill, G. Meintjes, G. Maartens   +8 more
semanticscholar   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1845-1856, June 2026.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Longer-term virologic outcomes on tenofovir-lamivudine-dolutegravir in second-line ART

Southern African Journal of HIV Medicine
Background: Dolutegravir in second-line antiretroviral therapy (ART) is more effective with recycled tenofovir than switching to zidovudine. However, dolutegravir resistance is more frequent in second-line compared to first-line ART.
Jennifer K. van Heerden, Ying Zhao, Claire M. Keene, Rulan Griesel, Zaayid Omar, René Goliath, Kayla Delaney, Gert van Zyl, Gary Maartens, Graeme Meintjes   +9 more
doaj   +1 more source

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

Gels, 2023
Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting ...
Anroop B Nair, S. Chaudhary, S. Jacob, Dhruvan Patel, P. Shinu, Hiral Shah, Ankit Chaudhary, Bandar E. Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, F. Alqattan, Jigar N. Shah   +11 more
semanticscholar   +1 more source

Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub‐Saharan Africa

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Introduction Congenital anomalies (CA) are ranked as the 3rd and 4th leading cause of neonatal and under‐5 mortality, respectively. Over 30% of infants born with a serious CA are found in sub‐Saharan Africa. Yet there are few robust epidemiological data on the burden and distribution of CA and associated mortality, disability, and morbidity ...
Emma Kalk, Helen Louise Malherbe, Ushma C. Mehta, Daniel Mumpe‐Mwanja, Modiegi Dianah Diseko, Adejumoke Idowu Ayede, Phyllis Kisa, Caroline Bonareri Osoro, George Bello, Lee Fairlie, Audrey Chepkemoi, Hamisi K. Shabani, Ali Sie, Samrawit Abebaw Tegene, Robert Serunjogi, Aminkeng Zawuo Leke, Helen Dolk, Linda Barlow Mosha, on behalf of the sub‐Saharan African Congenital Anomalies Network (sSCAN)   +18 more
wiley   +1 more source

Tracheal Extramedullary Plasmacytoma Causing Near‐Complete Airway Obstruction in an HIV‐Positive Man: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT A 53‐year‐old HIV‐positive man presented with progressive dyspnea, hoarseness, and near‐complete tracheal obstruction. Computed tomography and rigid bronchoscopy identified a > 90% obstructing tracheal mass. Histopathology with immunohistochemistry confirmed extramedullary plasmacytoma.
Filmon Tsegay, Esmael Mohamed Dawud, Amsalu Bekele, Amsalu Bitew, Hanan Yusuf, Mohamed Kedir Shukri, Amina Yimaj Yonis, Yonas Damtew Bejiga, Endalew Dessie Birara, Hosea Manyazewal Anberber, Tamirat Godebo Woyimo   +10 more
wiley   +1 more source

An effective stability indicating RP-HPLC method for simultaneous estimation of Dolutegravir and Lamivudine in bulk and their tablet dosage form

Future Journal of Pharmaceutical Sciences, 2020
Background A Simple, sensitive, and specific stability indicating reverse phase HPLC method was developed for simultaneous estimation of Lamivudine and Dolutegravir in bulk and tablet dosage form.
Ramreddy Godela, Sowjanya G
doaj   +1 more source

Morphological Variants and Factors Associated With Neural Tube Defects at a Regional Referral Hospital

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Neural Tube Defects (NTDs) remain a significant public health concern, especially in low‐resource settings. This study investigated the morphological variants of NTDs and identified factors associated with their development among neonates at Mbarara Regional Referral Hospital (MRRH).
Benard Owere, Patience D. Nalumaga, Dauglas Nkoyooyo, Innocent Ayesiga   +3 more
wiley   +1 more source

Drug interactions between dolutegravir and artemether-lumefantrine or artesunate-amodiaquine

, 2018
Across sub-Saharan Africa, patients with HIV on antiretrovirals often get malaria and need cotreatment with artemisinin-containing therapies. We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether ...
Mohammed Lamorde, Julian Kaboggoza, Alieu Amara, Walimbwa, SI, Else, L, Winterberg, Markus, Chiong, J, Byakika-Kibwika, P, Stephen I Walimbwa, Catriona Waitt, Tarning, J, Joshua Gini, Lamorde, M, Tarning, Joel, Justin Chiong, Pauline Byakika-Kibwika, Amara, A, Kaboggoza, J, Markus Winterberg, Saye H Khoo, Joel Tarning, Waitt, C, Winterberg, M, Gini, J, Khoo, SH, Laura Else   +25 more
core   +1 more source