Results 101 to 110 of about 17,845 (225)

Prevalence and Correlates of Hyperglycemia Among People Living With HIV and TB on Dolutegravir‐Based Antiretroviral Therapy in Zimbabwe: A Cross‐Sectional Study

Health Science Reports
Background and Aims In low‐ and middle‐income countries, dolutegravir‐based antiretroviral therapy regimens are the preferred first‐line treatment for adults, adolescents, and children with human immunodeficiency virus (HIV).
Tafadzwa Zireva, Cuthbert Musarurwa, Arthur Mazhandu, Brenda Nherera, Shungu Munyati, Justen Manasa, Danai Tavonga Zhou, Donald Vhanda   +7 more
doaj   +1 more source

Efficacy, safety, and tolerability of dolutegravir-based ART regimen in Durban, South Africa: a cohort study

BMC Infectious Diseases
Background Dolutegravir is an integrase strand transfer inhibitor that has been recommended for use in first-line antiretroviral regimens by the World Health Organisation and is currently being rolled out globally.
N. Hurbans, P. Naidoo
semanticscholar   +1 more source

Dolutegravir and Risk of Neuropsychiatric Adverse Events: a Pharmacogenetic Study.

Dolutegravir treatment can lead to neuropsychiatric adverse events (NPAE). This study assessed the association between NPAE and polymorphisms in dolutegravir-related pharmacogenes, determined by next-generation sequencing panel testing.
Elens, Laure, de Timary, Philippe, Haufroid, Vincent, Philippeau, Magali, De Greef, Julien, Panin, Nadtha, Boland, Lidvine, Belkhir, Leïla, Vincent, Anne, Vandercam, Bernard, Yombi, Jean Cyr   +10 more
core   +1 more source

A comparison between two dolutegravir-based two-drug regimens as switch strategies in a multicentre cohort of HIV-1-infected patients

, 2018
BACKGROUND: Two-drug regimens are increasingly used in clinical practice as switch strategies. We compared the efficacy and safety of two dolutegravir-based dual therapies (DT): dolutegravir plus lamivudine (3TC group) versus DTG plus rilpivirine (RPV ...
Ciccullo, Arturo, De Luca, Andrea, Di Giambenedetto, Simona, Colafigli, Manuela, Baldin, Gianmaria   +4 more
core   +1 more source

Systematic De-escalation of Successful Triple Antiretroviral Therapy to Dual Therapy with Dolutegravir plus Emtricitabine or Lamivudine in Swiss HIV-positive Persons

EClinicalMedicine, 2018
Background: Studies increasingly suggest that the efficacy of certain dual antiretroviral therapy (ART) combinations is equal to triple ART. Increasing concerns among HIV-positive patients and physicians in Switzerland include ART cost and long-term ART ...
Natascha D. Diaco, Claudio Strickler, Stéphanie Giezendanner, Sebastian A. Wirz, Philip E. Tarr   +4 more
doaj   +1 more source

The Activity of the Integrase Inhibitor Dolutegravir Against HIV-1 Variants Isolated From Raltegravir-Treated Adults [PDF]

, 2012
BACKGROUND: Dolutegravir (DTG, S/GSK1349572) is an integrase inhibitor with low nanomolar potency. Susceptibility to dolutegravir and raltegravir was determined for raltegravir-resistant clinical isolates. METHODS: Genotypic and phenotypic susceptibility
Johns, Brian A, Deeks, Steven G, Martin, Jeffrey N, Sato, Akihiko, Underwood, Mark R, Fujiwara, Tamio   +5 more
core   +1 more source

Determinants of early change in serum creatinine after initiation of dolutegravir-based antiretroviral therapy in South Africa

British Journal of Clinical Pharmacology
Dolutegravir increases serum creatinine by inhibiting its renal tubular secretion and elimination. We investigated determinants of early changes in serum creatinine in a southern African cohort starting first‐line dolutegravir‐based antiretroviral ...
Rephaim Mpofu, A. Kawuma, R. Wasmann, Godspower Akpomiemie, N. Chandiwana, Simiso M Sokhela, Michelle A. Moorhouse, W. D. F. Venter, P. Denti, L. Wiesner, Frank A. Post, David W. Haas, G. Maartens, P. Sinxadi   +13 more
semanticscholar   +1 more source

Rapid emergence of dolutegravir resistance on second-line dolutegravir-based ART

The integrase strand transfer inhibitor, dolutegravir (DTG), is widely used in first- and second-line antiretroviral therapy (ART) regimens in South Africa.
Moodley, Pravi, Sookrajh, Yukteshwar, Naidoo, Kirusha, Moosa, Mahomed Y S, Lessells, Richard J, Drain, Paul K, Garrett, Nigel, Dorward, Jienchi   +7 more
core   +1 more source

Sustained viral suppression with co-administration of oxcarbazepine and dolutegravir

, 2018
Co-administration of dolutegravir and oxcarbazepine has been reported to reduce levels of dolutegravir and therefore is contraindicated due to insufficient data to make dosing recommendations.
Christopher A Schriever, Manar M Kandil, Melissa E Badowski   +2 more
core   +1 more source

Serum Lipid Profiles, Blood Glucose, and High-Sensitivity C-Reactive Protein Levels Among People Living with HIV Taking Dolutegravir and Ritonavir-Boosted Atazanavir-Based Antiretroviral Therapy at Jimma University Medical Center, Southwest Ethiopia, 2021

HIV/AIDS
Background Long-term use of antiretroviral therapy, especially dolutegravir and boosted-atazanavir, raises concerns about cardiovascular disease. Thus, this study aimed to assess lipid profiles, blood glucose, and high-sensitivity C-reactive protein ...
Nuredin Chura Waritu, S. K. Nair, Bihonegn Birhan, Tesfaye Adugna, G. Awgichew, Mohammed Jemal   +5 more
semanticscholar   +1 more source