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Impact of Genetic Variants in ABCG2, NR1I2, and UGT1A1 on the Pharmacokinetics of Dolutegravir in Children

Journal of Acquired Immune Deficiency Syndromes
Supplemental Digital Content is Available in the Text. Background: Dolutegravir plasma concentrations and pharmacokinetic (PK) parameters in children display considerable variability.
Stephen A. Spector +5 more
semanticscholar +1 more source

Different effects of the companion antiretroviral drugs on dolutegravir trough concentrations

AIDS (London)
Background: Dolutegravir is widely used in different dual and triple antiretroviral regimens. Here, we sought to investigate the effect of the companion antiretroviral drug(s) on dolutegravir plasma trough concentrations in persons with HIV, with a focus
Dario Cattaneo +5 more
semanticscholar +1 more source

Twice-Daily Dolutegravir Based Antiretroviral Therapy with One Month of Daily Rifapentine and Isoniazid (1HP) for TB Prevention.

Clinical Infectious Diseases
BACKGROUND One month of daily rifapentine + isoniazid (1HP) is an effective, ultrashort option for TB prevention in people with HIV (PWH). However, rifapentine may decrease antiretroviral drug concentrations and increase the risk of virologic failure ...
A. Podany +11 more
semanticscholar +1 more source

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