Results 41 to 50 of about 12,252,325 (244)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A constraint modeling framework for domain-specific languages
, 2022 S.20-29The growing usage of Domain Specific Modeling Languages (DSML) for architecture view frameworks induces a need for automatic verification of non-functional model properties like completeness and consistency.
Pschorn, Patrick +3 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Schema-based Ontological Representations of a Domain-Specific Scenario Modeling Language [PDF]
, 2018 The first step in designing a domain-specific simulation scenario definition language is constructing its ontology. The recently published Aviation Scenario Definition Language (ASDL) aims at providing a common platform to specify scenarios in the ...
Durak, Umut +3 more
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Historical Reasoning: The Interplay of Domain-Specific and Domain-General Aspects
, 2018 In this chapter, we explore the question of domain-general and domain-specific aspects of reasoning in history. Historical reasoning is a form of informal reasoning. There are no single procedures to reach a conclusion and there is no single clear-cut or
van Drie, J. +5 more
core +1 more source
Language in autism and specific language impairment: Where are the links? [PDF]
, 2008 It has been suggested that language impairment in autism is behaviourally, neurobiologically, and etiologically related to specific language impairment (SLI).
Williams, David M. +5 more
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source