Results 71 to 80 of about 1,517,268 (284)

Language-specific neural dynamics extend syntax into the time domain

open access: yesPLoS Biology
Studies of perception have long shown that the brain adds information to its sensory analysis of the physical environment. A touchstone example for humans is language use: to comprehend a physical signal like speech, the brain must add linguistic ...
Cas W. Coopmans   +4 more
doaj   +2 more sources

Interacting with vector databases by means of domain-specific language

open access: yesOpen Computer Science
Vector database management systems have been recognized as a crucial innovation in the era dominated by artificial intelligence, where vast and high-dimensional datasets are generated at unprecedented scales.
Akik Elena   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Practicing domain-specific languages [PDF]

open access: yesProceedings of the 21st ACM/IEEE International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings, 2018
This paper describes our experience in constructing a new Domain-Specific Language course at the graduate level whose objectives is to reconciliate concepts coming from Language Design as well as Modeling domains. We illustrate the course using the reactive systems application domain, which prevents us to fall back in a toy example pitfall.
Gonnord, Laure, Mosser, Sébastien
openaire   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Opt: A Domain Specific Language for Non-linear Least Squares Optimization in Graphics and Imaging

open access: yes, 2016
Many graphics and vision problems can be expressed as non-linear least squares optimizations of objective functions over visual data, such as images and meshes.
Bernstein, Gilbert   +8 more
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Multilingual search for cultural heritage archives via combining multiple translation resources [PDF]

open access: yes, 2007
The linguistic features of material in Cultural Heritage (CH) archives may be in various languages requiring a facility for effective multilingual search.
Debole, Franca   +4 more
core  

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