Results 71 to 80 of about 1,532,627 (279)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Language-specific neural dynamics extend syntax into the time domain

PLoS Biology
Studies of perception have long shown that the brain adds information to its sensory analysis of the physical environment. A touchstone example for humans is language use: to comprehend a physical signal like speech, the brain must add linguistic ...
Cas W. Coopmans, Helen de Hoop, Filiz Tezcan, Peter Hagoort, Andrea E. Martin   +4 more
doaj   +2 more sources

Towards a Domain Specific Language for a Scene Graph based Robotic World Model [PDF]

, 2014
Robot world model representations are a vital part of robotic applications. However, there is no support for such representations in model-driven engineering tool chains.
Blumenthal, Sebastian, Bruyninckx, Herman   +1 more
core  

Practicing domain-specific languages [PDF]

Proceedings of the 21st ACM/IEEE International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings, 2018
This paper describes our experience in constructing a new Domain-Specific Language course at the graduate level whose objectives is to reconciliate concepts coming from Language Design as well as Modeling domains. We illustrate the course using the reactive systems application domain, which prevents us to fall back in a toy example pitfall.
Gonnord, Laure, Mosser, Sébastien
openaire   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Declarative Domain-Specific Language For Data Mining [PDF]

, 2012
В роботі розглядається предметно-орієнтована мова аналітичної обробки даних, використання якої для створення сценаріїв обробки даних не потребує від експертів знання інструментальних мов програмування, що суттєво знижує трудомісткість процесу розробки ...
Boldak, A. O., Efremov, K. V., Болдак, А. О., Єфремов, К. В.   +3 more
core  

Q#: Enabling scalable quantum computing and development with a high-level domain-specific language

, 2018
Quantum computing exploits quantum phenomena such as superposition and entanglement to realize a form of parallelism that is not available to traditional computing.
Azariah, John, Geller, Alan, Granade, Christopher, Heim, Bettina, Kliuchnikov, Vadym, Mykhailova, Mariia, Paz, Andres, Roetteler, Martin, Svore, Krysta M., Troyer, Matthias   +9 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source