Results 71 to 80 of about 12,252,325 (244)

SmartMM: A Domain-Specific Large Language Model for Medical Microbiology

AI
Background: Large language models (LLMs) show considerable promise for medical question answering and reasoning. Their use in medical microbiology, however, remains constrained by limited domain-specific knowledge and the risk of hallucinated outputs ...
Yongqiang Gong, Ruiqi Ma, Xicheng Wang, Ruixi Li, Han Dong, Yijin Liu, Xi Peng, Quanle Guo, Yin Liu   +8 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Sectional domain specific languages

, 2009
Nowadays, many problems are solved by using a domain specific language (DSL), i.e., a programming language tailored to work on a particular application domain.
W. Cazzola, Ivan Speziale, I. Speziale, Walter Cazzola   +3 more
core   +1 more source

Let's Make Refactoring Tools User-extensible! [PDF]

, 2012
We present a framework for making a refactoring tool extensible, allowing users to define refactorings from scratch using the concrete syntax of the language, as well as to describe complex refactorings in a domain-specific language for scripting.
Huiqing Li, Simon Thompson, Thompson, Simon, Li, Huiqing   +3 more
core   +1 more source

Interacting with vector databases by means of domain-specific language

Open Computer Science
Vector database management systems have been recognized as a crucial innovation in the era dominated by artificial intelligence, where vast and high-dimensional datasets are generated at unprecedented scales.
Akik Elena, Vještica Marko, Dimitrieski Vladimir, Čeliković Milan, Kordić Slavica, Ristić Sonja   +5 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Domain-specific query languages

, 2016
Data is a valuable commodity, and while there are many methods for effectively processing data, at the core of many of these is a query language - either general purpose, such as SQL and SPARQL, or domain-specific.
Yenchi Jaskolski (12304532)
core   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Domain-specific modeling as an enabling technology for small and medium-sized enterprises

, 2022
Art. a5In this paper, we present experiences and the outcomes of applying domain-specific modeling techniques to the domain of diagnostic systems within an industry project.
Schäfer, C., Kuhn, T., Barkowski, D., Trapp, M.   +3 more
core   +1 more source

A Survey of Domain-Specific Fine-Tuned Large Language Models

IEEE Access
The advancement of large language models (LLMs), such as GPT-3, BERT, and Llama, has introduced a new era in natural language processing (NLP) as they have demonstrated exceptional capabilities across diverse tasks.
Paria Sarzaeim, Akramul Azim, Gary Bauer, Masoud Makrehchi   +3 more
doaj   +1 more source