Results 131 to 140 of about 4,969,023 (298)

TADA: Taxonomy Adaptive Domain Adaptation

, 2021
Traditional domain adaptation addresses the task of adapting a model to a novel target domain under limited or no additional supervision. While tackling the input domain gap, the standard domain adaptation settings assume no domain change in the output space.
Gong, R., Danelljan, M., Dai, D., Wang, W., Paudel, D., Chhatkuli, A., Yu, F., Van Gool, L.   +7 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Domain Adaptation for Retail Demand Prediction

IEEE Access
Predicting the demand of products in the retail industry is a complex task, especially when there are changes in the market. This paper examines three such market shifts in the retail industry: the COVID-19 pandemic, opening a new store, and introducing ...
Niloofar Tarighat, Maxime C. Cohen, James J. Clark   +2 more
doaj   +1 more source

Adaptive$^2$: Adaptive Domain Mining for Fine-grained Domain Adaptation Modeling

Advertising systems often face the multi-domain challenge, where data distributions vary significantly across scenarios. Existing domain adaptation methods primarily focus on building domain-adaptive neural networks but often rely on hand-crafted domain information, e.g., advertising placement, which may be sub-optimal.
Sun, Wenxuan, Yang, Zixuan, Wang, Yunli, Zhang, Zhen, Wang, Zhiqiang, Li, Yu, Yang, Jian, Yang, Yiming, Wen, Shiyang, Jiang, Peng, Gai, Kun   +10 more
openaire   +2 more sources

Interventional Domain Adaptation

, 2020
Domain adaptation (DA) aims to transfer discriminative features learned from source domain to target domain. Most of DA methods focus on enhancing feature transferability through domain-invariance learning. However, source-learned discriminability itself might be tailored to be biased and unsafely transferable by spurious correlations, \emph{i.e ...
Wen, Jun, Shui, Changjian, Kuang, Kun, Yuan, Junsong, Huang, Zenan, Gong, Zhefeng, Zheng, Nenggan   +6 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

TO-UGDA: target-oriented unsupervised graph domain adaptation

Scientific Reports
Graph domain adaptation (GDA) aims to address the challenge of limited label data in the target graph domain. Existing methods such as UDAGCN, GRADE, DEAL, and COCO for different-level (node-level, graph-level) adaptation tasks exhibit variations in ...
Zhuo Zeng, Jianyu Xie, Zhijie Yang, Tengfei Ma, Duanbing Chen   +4 more
doaj   +1 more source