Results 101 to 110 of about 803,494 (308)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
AHeuristicAlgorithmforBlockFastIndexReductioninDifferentialAlgebraicSystems
工程科学与技术, 2014 :In order to optimize the index reduction technology of sparse differential algebraic equations (DAEs) from multi-domain unified modeling software,a heuristic algorithm for block fast index reduction method(BFIRM) was proposed.
唐卷, 杨文强, 吴文渊, 冯勇
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Meta-models of repeated dissipative joints for damping design phase [PDF]
, 2014 Developing tools to predict dissipation in mechanical assemblies starting from the design process is a subject of increasing interest. Design phases imply numerous computations resulting from the use of families of models with varying properties ...
BALMES, Etienne, HAMMAMI, Chaima
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Active control for flutter suppression: an experimental investigation
, 2013 This paper describes an experimental study involving the implementation of the method of receptances to control binary flutter in a wind-tunnel aerofoil rig. The aerofoil and its suspension were designed as part of the project.
Cooper, J. E. +4 more
core
, 2008 —A fast-marching time-domain layered finite-element re-duction-recovery (LAFE-RR) method is proposed for high-frequency modeling and simulation of large-scale integrated circuits.
Dan Jiao, Houle Gan
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
3D Multi-Domain MFS Analysis of Sound Pressure Level Reduction Between Connected Enclosures
Archives of Acoustics, 2013 In this paper, the authors study the 3D propagation of sound waves between two closed spaces. The separation element between the two rooms is considered to include either a small opening or a homogeneous lightweight panel, coupling the two spaces.
Luıs GODINHO +2 more
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source