Results 121 to 130 of about 803,494 (308)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
AN ABSTRACT THEORY FOR THE DOMAIN REDUCTION METHOD
, 1991 The domain reduction method uses a nite group of symmetries of a system of linear equations arising by discretization of partial differential equations to obtain a decomposition into independent subproblems, which can be solved in parallel.
Craig C. Douglas, Jan Mandel
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IEEE AccessThe Partial Element Equivalent Circuit (PEEC) method has gained significant recognition as an electromagnetic computational technique known for its ability to represent electromagnetic phenomena using equivalent circuits.
Muhammad A. Khattak +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Damping System Designs using Nonlinear Frequency Analysis Approach [PDF]
, 2012 The main purpose of this thesis focuses on the investigation of the frequency domain analysis and design approaches for nonlinear damping systems. With the development of modern mechanical and civil engineering structures, the vibration control has ...
Guo, Pengfei
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A Tool-Supported Approach to Engineering HTN Planning Models
, 1998 Our research concerns formal, expressive, object centred languages and tools for use in engineering domains for planning applications. In this paper we extend our recent work on an object-centred language for encoding precondition planning domains to a ...
McCluskey, T.L. +3 more
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
On artefact reduction, segmentation and classification of 3D computed tomography imagery in baggage security screening [PDF]
, 2014 This work considers novel image-processing and computer-vision techniques to advance the automated analysis of low-resolution, complex 3D volumetric Computed Tomography (CT) imagery obtained in the aviation-security-screening domain. Novel research is
Mouton, Andre
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