Results 131 to 140 of about 803,494 (308)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Model reduction of fractional impedance spectra for time–frequency analysis of batteries, fuel cells, and supercapacitors

Carbon Energy
Joint time–frequency analysis is an emerging method for interpreting the underlying physics in fuel cells, batteries, and supercapacitors. To increase the reliability of time–frequency analysis, a theoretical correlation between frequency‐domain ...
Weiheng Li, Qiu‐An Huang, Yuxuan Bai, Jia Wang, Linlin Wang, Yuyu Liu, Yufeng Zhao, Xifei Li, Jiujun Zhang   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Advanced Domain Decomposition Method by Local and Mixed Lagrange Multipliers

, 2014
This paper presents development of an improved domain decomposition method for large scale structural problem that aims to provide high computational efficiency.
Bauchau, Olivier, Cho, Haeseong, Kwak, Junyoung, Shin, Sangjoon, Chun, Taeyoung   +4 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The radial integration boundary integral and integro-differential equation methods for numerical solution of problems with variable coefficients

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The boundary element method (BEM) has become a powerful method for the numerical solution of boundary-value problems (BVPs), due to its ability (at least ...
Al-Jawary, Majeed
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Transient simulation of complex electronic circuits and systems operating at ultra high frequencies [PDF]

, 2005
The electronics industry worldwide faces increasingly difficult challenges in a bid to produce ultra-fast, reliable and inexpensive electronic devices. Electronic manufacturers rely on the Electronic Design Automation (EDA) industry to produce consistent
Dautbegovic, Emira
core  

Modelling of photonic wire Bragg Gratings

, 2006
Some important properties of photonic wire Bragg grating structures have been investigate. The design, obtained as a generalisation of the full-width gap grating, has been modelled using 3D finite-difference time-domain simulations.
GNAN, Marco, R. M. De La Rue, RUE R., BASSI P, BASSI, PAOLO, De La Rue, R M, M. Gnan, Chong, H M H, H. M. H. Chong, CHONG H, Bellanca, G, Gnan, M, G. Bellanca, BELLANCA, Gaetano, Bassi, P   +14 more
core   +1 more source

On line prediction of roll grinding chatter based on EMD component and wavelet packet energy entropy

Jin'gangshi yu moliao moju gongcheng
To address the issue of partial feature loss in the single processing method within the time-frequency domain for roll grinding chatter, a combined time-frequency domain method is proposed to process signal feature.
Huanhuan ZHU, Yulun CHI, Mengmeng ZHANG, Li XIONG, Xiaoang YING   +4 more
doaj   +1 more source