Results 241 to 250 of about 83,143 (263)

Protein Reconstitution and 3D Domain Swapping

Current Protein & Peptide Science, 2002
The native structures of proteins are governed by a large number of non-covalent interactions yielding a high specificity for the native packing of structural elements. This allows for the reconstitution of proteins from disconnected polypeptide fragments.
Maria, Håkansson, Sara, Linse
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Three-dimensional domain duplication, swapping and stealing

Current Opinion in Structural Biology, 1997
Examination of multidomain and/or multimeric protein structures can reveal evolutionary paths to a more complex 3D organization. Over the past few years, proteins have been shown to evolve while preserving mutual domain organization and interfaces. The recent advances in understanding domain reorganization and mobility highlight the versatility and ...
J, Heringa, W R, Taylor
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Domain‐Swapping Design by Polyproline Rod Insertion

ChemBioChem, 2019
AbstractDuring domain swapping, proteins mutually interconvert structural elements to form a di‐/oligomer. Engineering this process by design is important for creating a higher order protein assembly with minimal modification. Herein, a simple design strategy is shown for domain‐swapping formation by loop deletion and insertion of a polyproline rod ...
Shota Shiga, Masaru Yamanaka, Wataru Fujiwara, Shun Hirota, Shuichiro Goda, Koki Makabe   +5 more
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Domain Swaps to Phenotype Shifts

Science Signaling, 2010
Systematic swapping of modular protein domains verifies a mechanism for generation of phenotypic diversity in yeast.
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RNase A oligomerization through 3D domain swapping is favoured by a residue located far from the swapping domains

Biochimie, 2011
Bovine pancreatic ribonuclease A forms 3D domain-swapped oligomers by lyophilization from 40% acetic acid solutions or if subjected to various thermally-induced denaturation procedures. Considering that the intrinsic swapping propensity of bovine seminal RNase, the only member of the pancreatic-type RNase super-family that is dimeric in nature, is ...
F. VOTTARIELLO, E. GIACOMELLI, FRASSON, ROBERTA, POZZI, NICOLA, DE FILIPPIS, VINCENZO, G. GOTTE   +5 more
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Domain Swapping in the Human Histamine H1 Receptor

The Journal of Pharmacology and Experimental Therapeutics, 2004
G-protein-coupled receptors (GPCRs) represent the largest family of receptors involved in transmembrane signaling. Although these receptors were generally believed to be monomeric entities, accumulating evidence supports the presence of GPCRs in multimeric forms.
Bakker, R.A., Dees, G., Carrillo, J.J., Booth, R.G., Lopez-Gimenez, J.F., Milligan, G., Strange, P.G., Leurs, R.   +7 more
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Domain swapping of CD4 upon dimerization

Proteins: Structure, Function, and Bioinformatics, 2004
AbstractIt has recently been shown that disulfide bond Cys130—Cys159 in domain 2 of monomeric CD4 is involved in the formation of CD4 disulfide‐bonded dimers on cell surfaces and that it can influence the permissiveness of cells to HIV infection. Because this disulfide bond is buried in the monomer, a large conformational change must take place in ...
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Evolution of protein function by Domain swapping

2001
Publisher Summary This chapter explores the use of large exchanges of structure (subdomains, domains, and whole proteins) to evolve new function in proteins. These include the formation of multifunctional proteins, tandem duplication, domain recruitment, and circular permutation.
M, Ostermeier, S J, Benkovic
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BCL-XL Dimerization by Three-dimensional Domain Swapping

Journal of Molecular Biology, 2006
Dimeric interactions among anti- and pro-apoptotic members of the BCL-2 protein family are dynamically regulated and intimately involved in survival and death functions. We report the structure of a BCL-X(L) homodimers a 3D-domain swapped dimer (3DDS).
Jason W, O'Neill, Michael K, Manion, Brendan, Maguire, David M, Hockenbery   +3 more
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Domain swapping of death domain superfamily: Alternative strategy for dimerization

International Journal of Biological Macromolecules, 2019
The role of death domain (DD) protein-mediated inter-protein interactions in cell death and immune cell signaling have been extensively investigated as they are tentative targets for therapeutic interventions and are involved in signal transduction. Structural studies, especially those involving the recent advanced cryo-electron microscopy, indicated ...
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