Results 101 to 110 of about 448,401 (310)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dominance learning in diploid genetic algorithms for dynamic optimization problems

, 2006
Copyright @ 2006 YangThis paper proposes an adaptive dominance mechanism for diploidy genetic algorithms in dynamic environments. In this scheme, the genotype to phenotype mapping in each gene locus is controlled by a dominance probability, which is ...
Yang, S, Shengxiang Yang, Yang, Shengxiang   +2 more
core   +1 more source

Semitotal domination versus domination and total domination in trees

RAIRO - Operations Research
A set S of vertices in G is a semitotal dominating set of G if it is a dominating set of G and every vertex in S is within distance 2 of another vertex of S. The semitotal domination number, γt2(G), is the minimum cardinality of a semitotal dominating set of G. Clearly, γ(G) ≤ γt2(G) ≤ γt(G). In this paper, for any nontrivial tree T that is not a star,
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Stochastic Dominance Analysis of iShares [PDF]

Country indices as represented by iShares exhibit non-normal return distributions with both skewness and kurtosis. Davidson and Duclos (2000) and Memmel (2003) provide procedures for determining the statistical significance of stochastic dominance ...
Dominic Gasbarro, Wing-Keung Wong, J. Kenton Zumwalt   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Consistent Testing for Stochastic Dominance: A Subsampling Approach [PDF]

We propose a procedure for estimating the critical values of the Klecan, McFadden, and McFadden (1990) test for first and second order stochastic dominance in the general k-prospect case. Our method is based on subsampling bootstrap.
Whang, Yoon-Jae, Esfandiar Maasoumi, Oliver Linton   +2 more
core   +4 more sources

Кваліфікація монопольного становища на ринках та підстави притягнення до відповідальності за зловживання ним

Теорія і практика правознавства, 2018
Стаття присвячена розгляду теоретичних та практичних питань визначення монопольного становища суб’єктів господарюваннята застосування відповідальності до правопорушників за зловживання ним.
T. І. Shvydka
doaj   +1 more source

Stochastic dominance, regret dominance and regret-theoretic dominance

EURO Journal on Decision Processes, 2013
It is well known that stochastic dominance alone is insufficient for ensuring preferences when individuals experience regret. In this paper, we study two additional notions of dominance: (a) regret-theoretic dominance, which characterizes preferences in regret theory and (b) regret dominance, which characterizes preferences in mean-risk models with ...
Chin Hon Tan, Joseph C. Hartman
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source