Results 121 to 130 of about 552,137 (300)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Stochastic Dominance Approach to Spanning [PDF]

We develop a Stochastic Dominance methodology to analyze if new assets expand theinvestment possibilities for rational nonsatiable and risk-averse investors.
Post, G.T.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

'Assessing market dominance': a comment and an extension [PDF]

Melnik et al. [Melnik, A., Shy, Oz, Stenbacka, R. Assessing market dominance. Journal of Economic Behavior and Organization 68, 63-72] have proposed a new statistic to assess market dominance.
Panagiotis Chronis, Vassilis Droucopoulos   +1 more
core  

On the equality of domination number and 2-domination number

Discussiones Mathematicae Graph Theory
The 2-domination number $γ_2(G)$ of a graph $G$ is the minimum cardinality of a set $ D \subseteq V(G) $ for which every vertex outside $ D $ is adjacent to at least two vertices in $ D $. Clearly, $ γ_2(G) $ cannot be smaller than the domination number $ γ(G) $.
Gülnaz Boruzanli Ekinci, Csilla Bujtás
openaire   +5 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A GENERALIZED STOCHASTIC DOMINANCE PROGRAM FOR THE IBM PC [PDF]

A microcomputer program to perform Generalized Stochastic Dominance (GSD), Quasi-Second Degree Dominance (SSD), and Quasi-First Degree Stochastic Dominance (FSD) is described.
Cochran, Mark J., Goh, Siew, Shih, Chao-Chyuan, Raskin, Rob   +3 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Testing for Stochastic Dominance with Diversification Possibilities [PDF]

We derive empirical tests for stochastic dominance that allow for diversification betweenchoice alternatives. The tests can be computed using straightforward linearprogramming.
Post, G.T.
core  

Effects of social hierarchy in primiparous and multiparous goats on nursing behavior during lactation

Frontiers in Ethology
IntroductionGoats are gregarious animals with a social organization differentiated by their stratification into defined social ranks. Relatively little is known about whether these social relationships affect the behavioral activity of mothers and ...
Andrea García-Cázares, Paolo Cano-Suárez, Angélica Terrazas-García   +2 more
doaj   +1 more source