Results 61 to 70 of about 25,757 (296)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Effects of the Persistent Dominant Follicle on the Ability of Follicle Stimulating Hormone to Induce Follicle Development and Ovulatory Responses

Journal of Dairy Science, 2001
Three experiments were conducted to evaluate the effect of an induced first wave persistent dominant follicle on folliculogenesis and ovulatory responses induced by FSH. On d 6 of a synchronized estrous cycle (d 0 = estrus), cows were treated with a Syncromate-B implant and two injections of PGF2, (25 mg, 0700 h; 15 mg, 1900 h, i.m.).
T, Diaz, S M, Pancarci, M, Drost, E J, Schmitt, J D, Ambrose, W E, Fredriksson, W W, Thatcher   +6 more
openaire   +2 more sources

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation

G3: Genes, Genomes, Genetics, 2017
The Drosophila melanogaster ovarian follicle cell lineage provides a powerful system for investigating how epigenetic changes contribute to differentiation.
Ming-Chia Lee, Andrew D. Skora, Allan C. Spradling   +2 more
doaj   +1 more source

Reproductive performance of fixed-time artificial insemination in heifers supplemented with a homeopathic complex

Semina: Ciências Agrárias, 2022
For this study, ½ blood nelore × aberdeen angus heifers (n = 40; 14 months) were divided into two groups: control (n=20; 310 kg) and pró-cio (n=20; 304 kg).
Emanuel Binotto Ferreira, Gustavo Martins Gomes dos Santos, Sofia Botsaris Delchiaro, Tamires Korchovei Sanches, Fabio Morotti, Marcelo Marcondes Seneda   +5 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Effect of breeding season and age on follicular dynamics and hemodynamics in embryo donor mares subjected to luteolysis after embryo flushing

Open Veterinary Journal
Background: Mares are the only companion animal simulating women in the large diameter of their follicle, the effect of aging on reproduction and even mares are more sensitive to summer heat stress as they can sweat like human.
Jamal M.H. Alkhadrawy, Amal M. Aboelmaaty, Mostafa M. Abou-Ahmed, Abdelraouf M. Ghallab   +3 more
doaj   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

HPLC/MS-MS Analysis of Dominant Follicle Mineralocorticoid and Glucocorticoid Concentrations Collected after Ovariectomy.

, 2014
Difference in mineralocorticoid (A) and glucocorticoid (B) concentration in dominant follicle determined by HPLC/MS-MS (Biocrates Life Sciences AG) analysis for High A4 (black bars) and Low (white bars) A4 cows.*P≤0.05.
Rebecca J. Vinton (645803), Jennifer R. Wood (645807), Brizett D. Cole (645802), William E. Pohlmeier (645800), Andrea S. Cupp (645806), Renee M. McFee (645805), Robert A. Cushman (487364), Kevin M. Sargent (645801), Adam F. Summers (645799), Scott G. Kurz (645804)   +9 more
core   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source