Results 81 to 90 of about 50,631 (303)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Follicular Development Dynamics and Plasma Progesterone Profile during the Estrous Cycle of Dairy Cows

Animal Production: Indonesian Journal of Animal Production, 2008
A total of five local Friesian cows, 4 to 5 years, healthy, reproductively sound, were used in the study to understand the development dynamics of dominant follicles and plasma progesterone profile during estrous cycle.
PP Putro, R Wasito, H Wuryastuty, S Indarjulianto   +3 more
doaj  

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Turing Patterns and Biological Explanation [PDF]

, 2017
Turing patterns are a class of minimal mathematical models that have been used to discover and conceptualize certain abstract features of early biological development.
Amundson, Baker, Baker, Baron, Batterman, Bechtel, Bechtel, Bechtel, Bourgine, Brigandt, Brigandt, Cooper, Craver, Dilão, Dretske, Economou, Fox Keller, Horvath, Kondo, Lange, Levy, Love, Love, Love, Madzvamuse, Maini, Maini, Meinhardt, Meinhardt, Murray, Murray, Nathan, Othmer, Pincock, Pincock, Pincock, Pincock, Pincock, Sauer, Tompkins, Weisberg, Winther, Woody   +42 more
core   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary [PDF]

, 2001
Although ovarian follicle growth is under the influence of many growth factors and hormones of which FSH remains one of the most prominent regulators.
Durlinger, A.L.L. (Alexandra), Grootegoed, J.A. (Anton), Gruijters, M.J.G. (Maria), Jong, F.H. (Frank) de, Karels, B. (Bas), Kramer, P., Kumar, T.R. (Rajendra), Matzuk, M.M., Rose, U.M., Themmen, A.P.N. (Axel), Uilenbroek, J.Th.J. (Jan)   +10 more
core   +3 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Ovarian follicular activity and hormonal profile during estrous cycle in cows: the development of 2 versus 3 waves

Reproductive Biology and Endocrinology, 2003
Most estrous cycles in cows consist of 2 or 3 waves of follicular activity. Waves of ovarian follicular development comprise the growth of dominant follicles some of which become ovulatory and the others are anovulatory.
Noseir Wael MB
doaj   +1 more source

Insulin-like growth factor binding protein-2, 28 kDa an 24 kDa insulin-like growth factor binding protein levels are decreased in fluid of dominant follicles, obtained from normal and polycystic ovaries [PDF]

, 1993
In order to investigate potential changes in insulin-like growth factor binding proteins (IGFBPs) during human follicle maturation, we examined the IGFBP profiles in follicular fluid from follicles in different stages of maturation. Samples were obtained
Drop, S.L.S. (Stenvert), Fauser, B.C.J.M. (Bart), Lindenbergh-Kortleve, D.J. (Dicky), Pache, T.D., Schuller, A.G.P. (Alwin), Zwarthoff, E.C. (Ellen)   +5 more
core   +1 more source